Gene Expression Image Detail

Reference

Figure

ID

J:111589 Fisher DA, et al., Dev Dyn. 2006 Jul 31;235(9):2620-2630

3

MGI:3691488

Image

Caption

A-C: Sagittal sections of whole embryos at E14.5. Central nervous system (CNS), salivary glands (sal) and kidneys (kd). D-F: Horizontal sections of forebrain at E14.5. G: Close-up of horizontal section through the ventricular proliferative zone at the level of the lateral ganglionic eminence, showing Dact1 expression in radially arranged cell clusters (arrows). H-J: Horizontal sections at progressively more caudal planes of the E14.5 CNS. H: Midbrain. I: Midbrain/hindbrain junction and pons. J: Spinal cord. tc, tectum/dorsal midbrain; vm, ventral midbrain; mn, migrating neurons of the ventral midbrain; hy, hypothalamic nuclei; pt, pontine tegmentum; rl, rhombic lip of the fourth ventricle; cpr, cerebellar precursors; dh, developing dorsal horn of the spinal cord. Arrows indicate neurons in the motor pools of the ventral spinal cord (vsc). K: Horizontal section through spinal cord (sc) and sympathetic ganglia (sg). Compare to higher level of expression in the nearby edge of the developing thymus (thy). L: Section of developing kidney showing high levels of expression in the collecting system and renal pelvis (rp). M: Section through the main lobe of the thymus (thy). N: Section of the oral cavity showing expression in the developing salivary glands (sal) as well as weaker expression in the tooth buds (thb). O-Q: Sagittal sections of adult brains. All three genes are expressed in the hippocampus (hc), in different patterns in the cerebral cortex (Ccx), and other structures of the forebrain (see text). Insets: Expression in the adult cerebellum. Dact1 (inset O) is specifically expressed in the granule cell layer (gcl), whereas both Dact2 (inset P) and Dact3 (inset Q) are expressed significantly in the Purkinje cell layer (Pcl). fb, forebrain; mb, midbrain; hb, hindbrain; thal, adult thalamus; str, striatum; t, thalamic eminence; p, pons; lvr, liver; hl, hindlimb; cp, cortical plate zone; ne, neuroepithelium; lge, lateral ganglionic eminence; mge, medial ganglionic eminence; ml, molecular layer of the cerebellum; bl, extravasated blood. Asterisks indicate folded tissue. Scale bars = 1mm in A-C; 0.2mm in D-N; 2mm in O-Q.

Copyright

This image is from Fisher DA, Dev Dyn 2006 Jul 31;235(9):2620-2630 and is displayed with the permission of Wiley-Blackwell, who owns the Copyright.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A	MGI:3691489 (Dact1)
B	MGI:3691491 (Dact2)
C	MGI:3691493 (Dact3)
D	MGI:3691489 (Dact1)
E	MGI:3691491 (Dact2)
F	MGI:3691493 (Dact3)
G	MGI:3691489 (Dact1)
H	MGI:3691489 (Dact1)
I	MGI:3691489 (Dact1)
J	MGI:3691489 (Dact1)
K	MGI:3691491 (Dact2)
L	MGI:3691491 (Dact2)
M	MGI:3691491 (Dact2)
N	MGI:3691491 (Dact2)
O	MGI:3691489 (Dact1)
P	MGI:3691491 (Dact2)
Q	MGI:3691493 (Dact3)
O inset	MGI:3691489 (Dact1)
P inset	MGI:3691491 (Dact2)
Q inset	MGI:3691493 (Dact3)