Gene Expression Image Detail

Reference

Figure

ID

J:63183 Kramer PR, et al., Mech Dev. 2000 Jun;94(1-2):79-94

7

MGI:3043828

Image

Caption

Immunostaining for Ki67 indicated positive cells (A, brown nuclear staining, arrowhead; higher magnification shown in B) associated with LHRH-expressing cells (black staining, white arrowhead) emerging from the respiratory epithelium in an E15.5 mutant mouse. An LHRH cell, adjacent to the lateral edge of the respiratory epithelium, was-positive for Ki67 (white arrowhead). Apposed to this coexpressing cell is a cluster of LHRH-positive/Ki67-negative cells (B, arrow). LHRH cells in the respiratory epithelium (C, dashed line delimits the respiratory epithelium) were associated with Ki67-positive cells (black arrowheads) and one cell (open arrowhead) is positive for both LHRH (black reaction product) and Ki67 (brown nucleus), while another was positive for LHRH only (arrow). Olf-1 staining (D, brown nuclei) decreases dramatically (line) before the respiratory epithelium (re) in AP-2 a mutants. Note: very few Olf-1-positive nuclei are found in the respiratory epithelium (inset high magnification of (re) in D). Adjacent section (E) indicates LHRH cells (black cells, arrows) within the respiratory epithelial region negative for Olf-1 (D) are adjacent to Ki67-positive cells (brown cells, arrowheads). c, cartilage; oe, olfactory epithelium; re, respiratory epithelium. Bar = 20 microns (B,C); 100 microns (A); 200 microns (D,E).

Copyright

Reprinted with permission from Elsevier from doi:10.1016/S0925-4773(00)00316-6 Mech Dev 94: 79-94, Kramer PR; Guerrero G; Krishnamurthy R; Mitchell PJ; Wray S, Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha Copyright 2000

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A	MGI:3043831 (Gnrh1) MGI:3043837 (Mki67)
B	MGI:3043831 (Gnrh1) MGI:3043837 (Mki67)
C	MGI:3043831 (Gnrh1) MGI:3043837 (Mki67)
D	MGI:3043835 (Ebf1)
E	MGI:3043831 (Gnrh1) MGI:3043837 (Mki67)