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Vertebrate Homology
Source
 Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat, zebrafish)  
Alliance Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)		 Associated Human Diseases Sequences
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human NLRP3 HGNC:16400 (HGNC)
114548 (Entrez Gene)
606416 (OMIM)
NLRP3 (Alliance of Genome Resources)
 Chr1 q44 Chr1:247332331-247449108 (+)
GRCh38 		autosomal dominant nonsyndromic deafness 34
CINCA Syndrome
familial cold autoinflammatory syndrome 1
Muckle-Wells syndrome
urticaria
 Q96P20 (UniProt | EBI)
NM_004895 (RefSeq)
mouse Nlrp3 MGI:2653833 (MGI)
216799 (Entrez Gene)
Gene Tree
Nlrp3 (Alliance of Genome Resources)
 Chr11 37.73 cM Chr11:59432395-59457781 (+)
GRCm39 		CINCA Syndrome
familial cold autoinflammatory syndrome 1
metabolic dysfunction-associated steatotic liver disease
 216799 (NCBI Gene Model)
Q8R4B8 (UniProt | EBI)
NM_145827 (RefSeq)
rat Nlrp3 RGD:1308314 (Rat Genome Database)
287362 (Entrez Gene)
Nlrp3 (Alliance of Genome Resources)
 Chr10 q22 D4A523 (UniProt | EBI)
NM_001191642 (RefSeq)
zebrafish nlrc7 ZDB-GENE-070912-478 (Zebrafish Model Organism Database)
556007 (Entrez Gene)
nlrc7 (Alliance of Genome Resources)
 Chr22 XP_021325236 (RefSeq)
nlrc8 ZDB-GENE-070912-363 (Zebrafish Model Organism Database)
795668 (Entrez Gene)
nlrc8 (Alliance of Genome Resources)
 Chr15 XP_068069895 (RefSeq)
nlrc9 ZDB-GENE-070912-362 (Zebrafish Model Organism Database)
570229 (Entrez Gene)
nlrc9 (Alliance of Genome Resources)
 Chr15 NP_001410203 (RefSeq)
NM_001423274 (RefSeq)
nlrc11 ZDB-GENE-121214-30 (Zebrafish Model Organism Database)
100536895 (Entrez Gene)
nlrc11 (Alliance of Genome Resources)
 Chr15 XP_003200133 (RefSeq)
nlrp3 ZDB-GENE-070424-110 (Zebrafish Model Organism Database)
567964 (Entrez Gene)
nlrp3 (Alliance of Genome Resources)
 Chr1 XP_068078248 (RefSeq)
nlrp3l2 ZDB-GENE-221121-1 (Zebrafish Model Organism Database)
100535428 (Entrez Gene)
nlrp3l2 (Alliance of Genome Resources)
 ChrUN XP_021326653 (RefSeq)
nlrp12l ZDB-GENE-090313-181 (Zebrafish Model Organism Database)
792926 (Entrez Gene)
nlrp12l (Alliance of Genome Resources)
 Chr23 XP_005162399 (RefSeq)
rnh1 ZDB-GENE-030131-4718 (Zebrafish Model Organism Database)
569436 (Entrez Gene)
rnh1 (Alliance of Genome Resources)
 Chr22 XP_068072660 (RefSeq)
si:ch73-24k9.2 ZDB-GENE-121214-29 (Zebrafish Model Organism Database)
100332228 (Entrez Gene)
si:ch73-24k9.2 (Alliance of Genome Resources)
 Chr19 XP_017207901 (RefSeq)
si:ch73-50f9.4 ZDB-GENE-131122-9 (Zebrafish Model Organism Database)
799740 (Entrez Gene)
si:ch73-50f9.4 (Alliance of Genome Resources)
 Chr17 NP_001352668 (RefSeq)
NM_001365739 (RefSeq)
si:ch73-168d20.1 ZDB-GENE-121214-44 (Zebrafish Model Organism Database)
795914 (Entrez Gene)
si:ch73-168d20.1 (Alliance of Genome Resources)
 Chr23 XP_009295444 (RefSeq)
si:ch73-236c18.2 ZDB-GENE-121214-2 (Zebrafish Model Organism Database)
101884123 (Entrez Gene)
si:ch73-236c18.2 (Alliance of Genome Resources)
 Chr1 XP_068078272 (RefSeq)
si:ch73-236c18.5 ZDB-GENE-121213-7 (Zebrafish Model Organism Database)
100334029 (Entrez Gene)
si:ch73-236c18.5 (Alliance of Genome Resources)
 Chr1
si:ch73-286h23.3 ZDB-GENE-070705-236 (Zebrafish Model Organism Database)
569265 (Entrez Gene)
si:ch73-286h23.3 (Alliance of Genome Resources)
 Chr22 XP_005174054 (RefSeq)
si:ch211-15j1.1 ZDB-GENE-081031-25 (Zebrafish Model Organism Database)
100148972 (Entrez Gene)
si:ch211-15j1.1 (Alliance of Genome Resources)
 Chr1 XP_021333536 (RefSeq)
si:ch211-15j1.5 ZDB-GENE-081031-11 (Zebrafish Model Organism Database)
100148489 (Entrez Gene)
si:ch211-15j1.5 (Alliance of Genome Resources)
 Chr1 XP_009293975 (RefSeq)
si:ch211-76m11.3 ZDB-GENE-041210-276 (Zebrafish Model Organism Database)
108183497 (Entrez Gene)
si:ch211-76m11.3 (Alliance of Genome Resources)
 Chr4 NP_001353367 (RefSeq)
NM_001366438 (RefSeq)
si:ch211-114l13.1 ZDB-GENE-070424-109 (Zebrafish Model Organism Database)
566121 (Entrez Gene)
si:ch211-114l13.1 (Alliance of Genome Resources)
 Chr1
si:ch211-133h13.1 ZDB-GENE-141215-1 (Zebrafish Model Organism Database)
108184000 (Entrez Gene)
si:ch211-133h13.1 (Alliance of Genome Resources)
 Chr4 XP_017211266 (RefSeq)
si:ch211-149a19.3 ZDB-GENE-081104-128 (Zebrafish Model Organism Database)
568118 (Entrez Gene)
si:ch211-149a19.3 (Alliance of Genome Resources)
 Chr19 XP_021323904 (RefSeq)
si:ch211-181d7.1 ZDB-GENE-121214-14 (Zebrafish Model Organism Database)
100149909 (Entrez Gene)
si:ch211-181d7.1 (Alliance of Genome Resources)
 Chr15 XP_021322169 (RefSeq)
si:ch211-181d7.2 ZDB-GENE-131121-646 (Zebrafish Model Organism Database)
110437747 (Entrez Gene)
si:ch211-181d7.2 (Alliance of Genome Resources)
 Chr15 XP_017206756 (RefSeq)
si:ch211-187g4.1 ZDB-GENE-070912-161 (Zebrafish Model Organism Database)
110437934 (Entrez Gene)
si:ch211-187g4.1 (Alliance of Genome Resources)
 Chr15 NP_001410195 (RefSeq)
NM_001423266 (RefSeq)
si:ch211-196h16.5 ZDB-GENE-081029-8 (Zebrafish Model Organism Database)
561595 (Entrez Gene)
si:ch211-196h16.5 (Alliance of Genome Resources)
 Chr1 XP_068078004 (RefSeq)
si:ch211-197e7.1 ZDB-GENE-081103-26 (Zebrafish Model Organism Database)
100331576 (Entrez Gene)
si:ch211-197e7.1 (Alliance of Genome Resources)
 Chr4 XP_068076235 (RefSeq)
si:ch211-205a14.7 ZDB-GENE-050420-404 (Zebrafish Model Organism Database)
108183495 (Entrez Gene)
si:ch211-205a14.7 (Alliance of Genome Resources)
 Chr4 XP_068076926 (RefSeq)
si:ch211-207e19.2 ZDB-GENE-041210-227 (Zebrafish Model Organism Database)
565475 (Entrez Gene)
si:ch211-207e19.2 (Alliance of Genome Resources)
 Chr4 XP_017210847 (RefSeq)
si:ch211-213a13.5 ZDB-GENE-050208-711 (Zebrafish Model Organism Database)
108181095 (Entrez Gene)
si:ch211-213a13.5 (Alliance of Genome Resources)
 Chr22 XP_021325360 (RefSeq)
si:ch211-226o13.1 ZDB-GENE-081104-491 (Zebrafish Model Organism Database)
101886579 (Entrez Gene)
si:ch211-226o13.1 (Alliance of Genome Resources)
 Chr4 XP_068076151 (RefSeq)
si:ch211-232d10.1 ZDB-GENE-081103-11 (Zebrafish Model Organism Database)
108183520 (Entrez Gene)
si:ch211-232d10.1 (Alliance of Genome Resources)
 Chr4 XP_017210912 (RefSeq)
si:ch211-278p9.2 ZDB-GENE-081028-37 (Zebrafish Model Organism Database)
100537130 (Entrez Gene)
si:ch211-278p9.2 (Alliance of Genome Resources)
 Chr17 XP_017207240 (RefSeq)
si:dkey-11n14.1 ZDB-GENE-060503-332 (Zebrafish Model Organism Database)
100534940 (Entrez Gene)
si:dkey-11n14.1 (Alliance of Genome Resources)
 Chr4 XP_068075928 (RefSeq)
si:dkey-23k10.2 ZDB-GENE-131122-52 (Zebrafish Model Organism Database)
565381 (Entrez Gene)
si:dkey-23k10.2 (Alliance of Genome Resources)
 Chr15 XP_017206561 (RefSeq)
si:dkey-26m3.3 ZDB-GENE-070705-445 (Zebrafish Model Organism Database)
100148609 (Entrez Gene)
si:dkey-26m3.3 (Alliance of Genome Resources)
 Chr4 XP_068076149 (RefSeq)
si:dkey-71l4.3 ZDB-GENE-120703-25 (Zebrafish Model Organism Database)
108183518 (Entrez Gene)
si:dkey-71l4.3 (Alliance of Genome Resources)
 Chr4 XP_068076639 (RefSeq)
si:dkey-82i20.1 ZDB-GENE-081104-500 (Zebrafish Model Organism Database)
100330030 (Entrez Gene)
si:dkey-82i20.1 (Alliance of Genome Resources)
 Chr4 XP_021331270 (RefSeq)
si:dkey-121n8.5 ZDB-GENE-070912-364 (Zebrafish Model Organism Database)
108179100 (Entrez Gene)
si:dkey-121n8.5 (Alliance of Genome Resources)
 Chr15 XP_021322159 (RefSeq)
si:dkey-121n8.7 ZDB-GENE-070912-366 (Zebrafish Model Organism Database)
108179098 (Entrez Gene)
si:dkey-121n8.7 (Alliance of Genome Resources)
 Chr15 XP_009290195 (RefSeq)
si:dkey-165e24.1 ZDB-GENE-081103-19 (Zebrafish Model Organism Database)
101884333 (Entrez Gene)
si:dkey-165e24.1 (Alliance of Genome Resources)
 Chr4 XP_017211145 (RefSeq)
si:dkey-165o8.1 ZDB-GENE-131118-7 (Zebrafish Model Organism Database)
108183519 (Entrez Gene)
si:dkey-165o8.1 (Alliance of Genome Resources)
 Chr4 XP_021330990 (RefSeq)
si:dkey-178j11.5 ZDB-GENE-131118-10 (Zebrafish Model Organism Database)
103910482 (Entrez Gene)
si:dkey-178j11.5 (Alliance of Genome Resources)
 Chr4 XP_017210814 (RefSeq)
si:dkey-222h21.3 ZDB-GENE-081031-31 (Zebrafish Model Organism Database)
795109 (Entrez Gene)
si:dkey-222h21.3 (Alliance of Genome Resources)
 Chr1 XP_001335224 (RefSeq)
si:dkey-222h21.4 ZDB-GENE-081031-28 (Zebrafish Model Organism Database)
795186 (Entrez Gene)
si:dkey-222h21.4 (Alliance of Genome Resources)
 Chr1
si:dkey-222h21.5 ZDB-GENE-081031-19 (Zebrafish Model Organism Database)
795257 (Entrez Gene)
si:dkey-222h21.5 (Alliance of Genome Resources)
 Chr1 XP_068078263 (RefSeq)
si:dkey-230i18.2 ZDB-GENE-070912-457 (Zebrafish Model Organism Database)
110437935 (Entrez Gene)
si:dkey-230i18.2 (Alliance of Genome Resources)
 Chr15
si:dkey-257e4.2 ZDB-GENE-070705-426 (Zebrafish Model Organism Database)
108183322 (Entrez Gene)
si:dkey-257e4.2 (Alliance of Genome Resources)
 Chr4 XP_021331271 (RefSeq)
si:dkeyp-15a6.2 ZDB-GENE-081029-4 (Zebrafish Model Organism Database)
108183920 (Entrez Gene)
si:dkeyp-15a6.2 (Alliance of Genome Resources)
 Chr4 NP_001410662 (RefSeq)
NM_001423733 (RefSeq)
si:dkeyp-100h4.1 ZDB-GENE-081103-7 (Zebrafish Model Organism Database)
103910657 (Entrez Gene)
si:dkeyp-100h4.1 (Alliance of Genome Resources)
 Chr4 XP_068076155 (RefSeq)
Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory