Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	BRCA1	HGNC:1100 (HGNC) 672 (Entrez Gene) 113705 (OMIM) BRCA1 (Alliance of Genome Resources)	Chr17 q21.31	Chr17:43044295-43170327 (-) GRCh38	breast adenocarcinoma breast cancer cervical cancer cervix uteri carcinoma in situ colon cancer colorectal cancer esophagus squamous cell carcinoma Fanconi anemia hereditary breast ovarian cancer syndrome hypertension lung non-small cell carcinoma nasopharynx carcinoma ovarian cancer pancreatic cancer prostate cancer stomach cancer urinary bladder cancer	P38398 (UniProt | EBI) NM_001407734 (RefSeq)
mouse	Brca1	MGI:104537 (MGI) 12189 (Entrez Gene) Gene Tree Brca1 (Alliance of Genome Resources)	Chr11 65.18 cM	Chr11:101379590-101442781 (-) GRCm39	breast cancer	ENSMUSG00000017146 (Ensembl Gene Model) ENSMUSP00000017290 (Ensembl) ENSMUST00000017290 (Ensembl)
rat	Brca1	RGD:2218 (Rat Genome Database) 497672 (Entrez Gene) Brca1 (Alliance of Genome Resources)	Chr10 q31			O54952 (UniProt | EBI) NM_012514 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.