Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	MAP2K4	HGNC:6844 (HGNC) 6416 (Entrez Gene) 601335 (OMIM) MAP2K4 (Alliance of Genome Resources)	Chr17 p12	Chr17:12020829-12143830 (+) GRCh38	colorectal cancer lung cancer lung non-small cell carcinoma nasopharynx carcinoma ovarian serous carcinoma pancreatic cancer urinary bladder cancer	P45985 (UniProt | EBI) NM_001281435 (RefSeq)
mouse	Map2k4	MGI:1346869 (MGI) 26398 (Entrez Gene) Gene Tree Map2k4 (Alliance of Genome Resources)	Chr11 40.53 cM	Chr11:65579069-65679123 (-) GRCm39		ENSMUSG00000033352 (Ensembl Gene Model) ENSMUSP00000041282 (Ensembl) ENSMUST00000046963 (Ensembl)
rat	Map2k4	RGD:1307040 (Rat Genome Database) 287398 (Entrez Gene) Map2k4 (Alliance of Genome Resources)	Chr10 q24			NP_001025194 (RefSeq) NM_001030023 (RefSeq)
zebrafish	map2k4a	ZDB-GENE-060512-98 (Zebrafish Model Organism Database) 403052 (Entrez Gene) map2k4a (Alliance of Genome Resources)	Chr3			NP_991299 (RefSeq) NM_205736 (RefSeq)
	map2k4b	ZDB-GENE-080721-13 (Zebrafish Model Organism Database) 568951 (Entrez Gene) map2k4b (Alliance of Genome Resources)	Chr12			NP_001082890 (RefSeq) NM_001089421 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.