Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	WT1	HGNC:12796 (HGNC) 7490 (Entrez Gene) 607102 (OMIM) WT1 (Alliance of Genome Resources)	Chr11 p13	Chr11:32387775-32435564 (-) GRCh38	Alzheimer's disease Denys-Drash syndrome Frasier syndrome malignant mesothelioma nephroblastoma nephrotic syndrome type 4 renal Wilms' tumor	P19544 (UniProt | EBI) NM_001429033 (RefSeq)
mouse	Wt1	MGI:98968 (MGI) 22431 (Entrez Gene) Gene Tree Wt1 (Alliance of Genome Resources)	Chr2 55.06 cM	Chr2:104956874-105003959 (+) GRCm39	congenital diaphragmatic hernia Denys-Drash syndrome	22431 (NCBI Gene Model) P22561 (UniProt | EBI) NM_144783 (RefSeq)
rat	Wt1	RGD:3974 (Rat Genome Database) 24883 (Entrez Gene) Wt1 (Alliance of Genome Resources)	Chr3 q33			P49952 (UniProt | EBI) NM_031534 (RefSeq)
zebrafish	wt1a	ZDB-GENE-980526-558 (Zebrafish Model Organism Database) 30245 (Entrez Gene) wt1a (Alliance of Genome Resources)	Chr25			NP_571121 (RefSeq) NM_131046 (RefSeq)
	wt1b	ZDB-GENE-050420-319 (Zebrafish Model Organism Database) 568416 (Entrez Gene) wt1b (Alliance of Genome Resources)	Chr18			NP_001034723 (RefSeq) NM_001039634 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.