Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IGF1R	HGNC:5465 (HGNC) 3480 (Entrez Gene) 147370 (OMIM) IGF1R (Alliance of Genome Resources)	Chr15 q26.3	Chr15:98648539-98964530 (+) GRCh38	clear cell renal cell carcinoma dementia hepatocellular carcinoma high grade glioma IgA glomerulonephritis Lewy body dementia liver cirrhosis nephroblastoma neuroblastoma osteoporosis pancreatic cancer portal vein thrombosis prostate adenocarcinoma toxic encephalopathy vascular dementia	P08069 (UniProt | EBI) NM_152452 (RefSeq)
mouse	Igf1r	MGI:96433 (MGI) 16001 (Entrez Gene) Gene Tree Igf1r (Alliance of Genome Resources)	Chr7 37.27 cM	Chr7:67602575-67883416 (+) GRCm39		ENSMUSG00000005533 (Ensembl Gene Model) ENSMUSP00000005671 (Ensembl) ENSMUST00000005671 (Ensembl)
rat	Igf1r	RGD:2869 (Rat Genome Database) 25718 (Entrez Gene) Igf1r (Alliance of Genome Resources)	Chr1 q22			P24062 (UniProt | EBI) NM_001414181 (RefSeq)
zebrafish	igf1ra	ZDB-GENE-020503-1 (Zebrafish Model Organism Database) 245701 (Entrez Gene) igf1ra (Alliance of Genome Resources)	Chr18			NP_694500 (RefSeq) NM_152968 (RefSeq)
	igf1rb	ZDB-GENE-020503-2 (Zebrafish Model Organism Database) 245702 (Entrez Gene) igf1rb (Alliance of Genome Resources)	Chr7			NP_694501 (RefSeq) NM_152969 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.