Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZNRF4
  • Mouse genes Znrf4
  • Rat genes Znrf4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Znrf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ZNRF4	IPI	UniProtKB:P27824	Human	PMID:21205830
Molecular Function	GO:0005515	protein binding	ZNRF4	IPI	UniProtKB:O00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZNRF4	IPI	UniProtKB:P21589	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZNRF4	IPI	UniProtKB:Q8N7U7-2	Human	PMID:32296183
Molecular Function	GO:0030292	protein tyrosine kinase inhibitor activity	ZNRF4	IDA		Human	PMID:28656966
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ZNRF4	IDA		Human	PMID:28656966
Cellular Component	GO:0005737	cytoplasm	Znrf4	IDA		Mouse	PMID:10191088
Cellular Component	GO:0005783	endoplasmic reticulum	ZNRF4	IDA		Human	PMID:28656966
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ZNRF4	IDA		Human	PMID:28656966
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ZNRF4	IDA		Human	PMID:21205830
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ZNRF4	IDA		Human	PMID:28656966
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ZNRF4	IDA		Human	PMID:21205830
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ZNRF4	IDA		Human	PMID:28656966

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern