Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TXNDC12
  • Mouse genes Txndc12
  • Rat genes Txndc12
  • Zfish genes txndc12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Txndc12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:O95198	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q96EQ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:O95198	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q9UMX0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:P49069	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q92785	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TXNDC12	IPI	UniProtKB:Q9Y680	Human	PMID:32296183
Molecular Function	GO:0019153	protein-disulfide reductase (glutathione) activity	TXNDC12	IDA		Human	PMID:12761212
Molecular Function	GO:0047134	protein-disulfide reductase (NAD(P)) activity	txndc12	IDA		Zfish	PMID:30359749
Molecular Function	GO:0015035	protein-disulfide reductase activity	TXNDC12	IDA		Human	PMID:18628206
Cellular Component	GO:0005783	endoplasmic reticulum	Txndc12	IDA		Mouse	PMID:18628206
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TXNDC12	IDA		Human	PMID:18628206
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TXNDC12	IDA		Human	PMID:12761212
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Txndc12	IDA		Mouse	MGI:MGI:3688339|PMID:12930873
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Txndc12	IDA		Rat	PMID:12930873|RGD:151356646
Biological Process	GO:0061691	detoxification of hydrogen peroxide	txndc12	IDA		Zfish	PMID:30359749
Biological Process	GO:0006974	DNA damage response	txndc12	IDA		Zfish	PMID:30359749
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	TXNDC12	IDA		Human	PMID:18628206

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern