Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNK1
  • Mouse genes Tnk1
  • Rat genes Tnk1
  • Zfish genes tnk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	TNK1	IDA		Human	PMID:10873601
Molecular Function	GO:0005524	ATP binding	Tnk1	IMP		Mouse	MGI:MGI:2664463|PMID:12789265
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Tnk1	IDA		Mouse	MGI:MGI:2664463|PMID:12789265
Molecular Function	GO:0005515	protein binding	TNK1	IPI	UniProtKB:P19174	Human	PMID:10873601
Molecular Function	GO:0005515	protein binding	TNK1	IPI	UniProtKB:P31947	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	TNK1	IPI	UniProtKB:P31947	Human	PMID:25852190
Molecular Function	GO:0004713	protein tyrosine kinase activity	TNK1	IDA		Human	PMID:10873601
Cellular Component	GO:0005737	cytoplasm	TNK1	IDA		Human	PMID:10873601
Cellular Component	GO:0005829	cytosol	Tnk1	IDA		Mouse	MGI:MGI:2664463|PMID:12789265
Cellular Component	GO:0016020	membrane	TNK1	IDA		Human	PMID:10873601
Biological Process	GO:0030308	negative regulation of cell growth	Tnk1	IMP		Mouse	MGI:MGI:2664463|PMID:12789265
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Tnk1	IMP		Mouse	MGI:MGI:2664463|PMID:12789265
Biological Process	GO:0046777	protein autophosphorylation	TNK1	IDA		Human	PMID:10873601
Biological Process	GO:0046777	protein autophosphorylation	Tnk1	IDA		Mouse	MGI:MGI:2664463|PMID:12789265

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern