Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM63C
  • Mouse genes Tmem63c
  • Rat genes Tmem63c
  • Zfish genes tmem63c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem63c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005227	calcium activated cation channel activity	TMEM63C	IDA		Human	PMID:24503647
Molecular Function	GO:1990760	osmolarity-sensing monoatomic cation channel activity	Tmem63c	IDA		Mouse	MGI:MGI:6378787|PMID:27045885
Cellular Component	GO:0005886	plasma membrane	Tmem63c	IDA		Mouse	MGI:MGI:6378787|PMID:27045885
Biological Process	GO:0003094	glomerular filtration	Tmem63c	IMP		Rat	PMID:30900988|RGD:15023481
Biological Process	GO:0003094	glomerular filtration	tmem63c	IMP		Zfish	PMID:30900988|ZFIN:ZDB-PUB-190323-8
Biological Process	GO:0003094	glomerular filtration	tmem63c	IMP	ZFIN:ZDB-CRISPR-191028-4	Zfish	PMID:30900988
Biological Process	GO:0003094	glomerular filtration	tmem63c	IMP	ZFIN:ZDB-MRPHLNO-191028-3	Zfish	PMID:30900988
Biological Process	GO:0003094	glomerular filtration	tmem63c	IMP	ZFIN:ZDB-MRPHLNO-191028-2	Zfish	PMID:30900988
Biological Process	GO:0032835	glomerulus development	tmem63c	IMP	ZFIN:ZDB-CRISPR-191028-4	Zfish	PMID:30900988
Biological Process	GO:0032835	glomerulus development	tmem63c	IMP	ZFIN:ZDB-MRPHLNO-191028-2	Zfish	PMID:30900988
Biological Process	GO:0032835	glomerulus development	tmem63c	IMP	ZFIN:ZDB-MRPHLNO-191028-3	Zfish	PMID:30900988
Biological Process	GO:0006812	monoatomic cation transport	TMEM63C	IDA		Human	PMID:24503647

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern