Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM63A
  • Mouse genes Tmem63a
  • Rat genes Tmem63a
  • Zfish genes tmem63a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem63a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	TMEM63A	IDA		Human	PMID:30382938
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	TMEM63A	IMP		Human	PMID:31587869
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Tmem63a	IDA		Mouse	MGI:MGI:6377838|PMID:30382938
Molecular Function	GO:1990760	osmolarity-sensing monoatomic cation channel activity	Tmem63a	IDA		Mouse	MGI:MGI:6378787|PMID:27045885
Molecular Function	GO:0005515	protein binding	TMEM63A	IPI	UniProtKB:O44126	Human	PMID:28870237
Cellular Component	GO:0034451	centriolar satellite	TMEM63A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	TMEM63A	HDA		Human	PMID:19056867
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TMEM63A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	TMEM63A	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	TMEM63A	IDA		Human	PMID:20957757
Cellular Component	GO:0005886	plasma membrane	Tmem63a	IDA		Mouse	MGI:MGI:6377838|PMID:30382938
Cellular Component	GO:0005886	plasma membrane	Tmem63a	IDA		Mouse	MGI:MGI:6378787|PMID:27045885

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern