Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THEMIS2
  • Mouse genes Themis2
  • Rat genes Themis2
  • Zfish genes themis2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Themis2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	THEMIS2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	THEMIS2	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Themis2	IPI	UniProtKB:P25911,UniProtKB:Q60631,UniProtKB:Q8CIH5	Mouse	MGI:MGI:5775861|PMID:24907343
Molecular Function	GO:0005515	protein binding	Themis2	IPI	PR:Q62245	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Themis2	IPI	PR:O54957	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Themis2	IPI	MGI:MGI:98923	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Themis2	IPI	PR:Q60631	Mouse	PMID:22732588
Cellular Component	GO:0005737	cytoplasm	Themis2	IDA		Mouse	PMID:22732588
Cellular Component	GO:0005634	nucleus	Themis2	IDA		Mouse	PMID:22732588
Biological Process	GO:0050864	regulation of B cell activation	Themis2	IMP		Mouse	MGI:MGI:5775861|PMID:24907343
Biological Process	GO:0050852	T cell receptor signaling pathway	Themis2	IMP		Mouse	PMID:22732588

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern