Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TDP2
  • Mouse genes Tdp2
  • Rat genes Tdp2
  • Zfish genes tdp2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tdp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	TDP2	IDA		Human	PMID:19794497
Molecular Function	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	TDP2	IMP		Human	PMID:21030584
Molecular Function	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	TDP2	IDA		Human	PMID:22405347
Molecular Function	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	TDP2	IDA		Human	PMID:22822062
Molecular Function	GO:0003677	DNA binding	tdp2b	IDA		Zfish	PMID:23104058
Molecular Function	GO:0000287	magnesium ion binding	TDP2	IDA		Human	PMID:22405347
Molecular Function	GO:0000287	magnesium ion binding	TDP2	IDA		Human	PMID:22822062
Molecular Function	GO:0030145	manganese ion binding	TDP2	IDA		Human	PMID:22822062
Molecular Function	GO:0005515	protein binding	TDP2	IPI	UniProtKB:Q61271	Human	PMID:18039968
Molecular Function	GO:0005515	protein binding	TDP2	IPI	UniProtKB:Q8BUN5	Human	PMID:18039968
Molecular Function	GO:0005515	protein binding	TDP2	IPI	UniProtKB:P51451	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TDP2	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP2	IPI	UniProtKB:P54252	Human	PMID:32814053
Molecular Function	GO:0003697	single-stranded DNA binding	TDP2	IDA		Human	PMID:22822062
Molecular Function	GO:0070259	tyrosyl-DNA phosphodiesterase activity	tdp2b	IDA		Zfish	PMID:29574079
Molecular Function	GO:0036317	tyrosyl-RNA phosphodiesterase activity	TDP2	IDA		Human	PMID:22908287
Cellular Component	GO:0016235	aggresome	TDP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	TDP2	IDA		Human	PMID:22908287
Cellular Component	GO:0016604	nuclear body	TDP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TDP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TDP2	IDA		Human	PMID:22908287
Cellular Component	GO:0016605	PML body	TDP2	IDA		Human	PMID:19794497
Biological Process	GO:0060027	convergent extension involved in gastrulation	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080307-1,ZFIN:ZDB-MRPHLNO-080309-1	Zfish	PMID:18039968
Biological Process	GO:0007368	determination of left/right symmetry	tdp2b	IMP		Zfish	PMID:18039968|ZFIN:ZDB-PUB-071129-9
Biological Process	GO:0007368	determination of left/right symmetry	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080309-2	Zfish	PMID:18039968
Biological Process	GO:0007368	determination of left/right symmetry	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080307-1	Zfish	PMID:18039968
Biological Process	GO:0007368	determination of left/right symmetry	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080309-1	Zfish	PMID:18039968
Biological Process	GO:0006302	double-strand break repair	TDP2	IDA		Human	PMID:19794497
Biological Process	GO:0006302	double-strand break repair	TDP2	IMP		Human	PMID:21030584
Biological Process	GO:0007369	gastrulation	tdp2b	IMP		Zfish	PMID:18039968|ZFIN:ZDB-PUB-071129-9
Biological Process	GO:0007369	gastrulation	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080309-2	Zfish	PMID:18039968
Biological Process	GO:0007369	gastrulation	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080309-1	Zfish	PMID:18039968
Biological Process	GO:0007369	gastrulation	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080307-1	Zfish	PMID:18039968
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	tdp2b	IMP	ZFIN:ZDB-MRPHLNO-080307-1,ZFIN:ZDB-MRPHLNO-080309-1	Zfish	PMID:18039968
Biological Process	GO:0048666	neuron development	TDP2	IMP		Human	PMID:24658003

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern