Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPTLC1
  • Mouse genes Sptlc1
  • Rat genes Sptlc1
  • Zfish genes sptlc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sptlc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPTLC1	IPI	UniProtKB:Q8NFR3	Human	PMID:19416851
Molecular Function	GO:0005515	protein binding	SPTLC1	IPI	UniProtKB:Q969W0	Human	PMID:19416851
Molecular Function	GO:0005515	protein binding	SPTLC1	IPI	UniProtKB:Q9NUV7	Human	PMID:19416851
Molecular Function	GO:0005515	protein binding	SPTLC1	IPI	UniProtKB:Q8N138	Human	PMID:20182505
Molecular Function	GO:0005515	protein binding	SPTLC1	IPI	UniProtKB:Q8N138	Human	PMID:33558761
Molecular Function	GO:0005515	protein binding	Sptlc1	IPI	UniProtKB:Q99P72	Mouse	MGI:MGI:5749304|PMID:26301690
Molecular Function	GO:0005515	protein binding	Sptlc1	IPI	PR:P41233	Mouse	PMID:18484747
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC1	IDA		Human	PMID:25332431
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC1	IDA		Human	PMID:25691431
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC1	IDA		Human	PMID:19416851
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	Sptlc1	IMP		Mouse	MGI:MGI:5896517|PMID:28100772
Cellular Component	GO:0005783	endoplasmic reticulum	SPTLC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Sptlc1	IDA		Mouse	MGI:MGI:5749304|PMID:26301690
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC1	IPI		Human	PMID:19416851
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC1	IPI		Human	PMID:33558761
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC1	IDA		Human	PMID:19416851
Cellular Component	GO:0035339	SPOTS complex	SPTLC1	IDA		Human	PMID:20182505
Cellular Component	GO:0035339	SPOTS complex	SPTLC1	IDA		Human	PMID:25691431
Biological Process	GO:0046513	ceramide biosynthetic process	SPTLC1	IDA		Human	PMID:25691431
Biological Process	GO:0046513	ceramide biosynthetic process	Sptlc1	IMP	MGI:MGI:3815115	Mouse	PMID:16216550
Biological Process	GO:0000132	establishment of mitotic spindle orientation	sptlc1	IMP	ZFIN:ZDB-MRPHLNO-201202-4	Zfish	PMID:32620775
Biological Process	GO:0000132	establishment of mitotic spindle orientation	sptlc1	IMP	ZFIN:ZDB-MRPHLNO-201202-2	Zfish	PMID:32620775
Biological Process	GO:0000132	establishment of mitotic spindle orientation	sptlc1	IMP	ZFIN:ZDB-MRPHLNO-201202-3	Zfish	PMID:32620775
Biological Process	GO:1904504	positive regulation of lipophagy	SPTLC1	IDA		Human	PMID:25332431
Biological Process	GO:1904649	regulation of fat cell apoptotic process	Sptlc1	IMP		Mouse	MGI:MGI:5896517|PMID:28100772
Biological Process	GO:0046511	sphinganine biosynthetic process	Sptlc1	IMP	MGI:MGI:3815115	Mouse	PMID:19416652
Biological Process	GO:0030148	sphingolipid biosynthetic process	SPTLC1	IDA		Human	PMID:25332431
Biological Process	GO:0006665	sphingolipid metabolic process	Sptlc1	IMP		Mouse	MGI:MGI:5896517|PMID:28100772
Biological Process	GO:0006686	sphingomyelin biosynthetic process	Sptlc1	IDA		Mouse	MGI:MGI:5749304|PMID:26301690
Biological Process	GO:0006686	sphingomyelin biosynthetic process	Sptlc1	IMP	MGI:MGI:3815115	Mouse	PMID:16216550
Biological Process	GO:0046512	sphingosine biosynthetic process	SPTLC1	IDA		Human	PMID:19416851
Biological Process	GO:0046512	sphingosine biosynthetic process	SPTLC1	IDA		Human	PMID:33558761
Biological Process	GO:0046512	sphingosine biosynthetic process	Sptlc1	IMP	MGI:MGI:3815115	Mouse	PMID:16216550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern