Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPRR2A,SPRR2B,SPRR2D,SPRR2E,SPRR2F
  • Mouse genes Sprr2d
  • Rat genes Sprr2b,Sprr2d
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sprr2d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008289	lipid binding	SPRR2A	IDA		Human	PMID:34735226
Molecular Function	GO:0005515	protein binding	SPRR2E	IPI	UniProtKB:P22735	Human	PMID:9722562
Molecular Function	GO:0005515	protein binding	SPRR2A	IPI	UniProtKB:P12931	Human	PMID:18155796
Molecular Function	GO:0030280	structural constituent of skin epidermis	SPRR2E	IDA		Human	PMID:7543090
Molecular Function	GO:0030280	structural constituent of skin epidermis	SPRR2E	IDA		Human	PMID:9722562
Cellular Component	GO:0001533	cornified envelope	SPRR2E	IDA		Human	PMID:7543090
Cellular Component	GO:0001533	cornified envelope	SPRR2E	IDA		Human	PMID:9722562
Cellular Component	GO:0005737	cytoplasm	SPRR2E	IDA		Human	PMID:3133554
Cellular Component	GO:0005737	cytoplasm	SPRR2D	IDA		Human	PMID:16639001
Cellular Component	GO:0005737	cytoplasm	SPRR2D	IDA		Human	PMID:3133554
Cellular Component	GO:0005737	cytoplasm	SPRR2A	IDA		Human	PMID:16639001
Cellular Component	GO:0005737	cytoplasm	Sprr2d	IDA		Mouse	MGI:MGI:3839158|PMID:19301398
Cellular Component	GO:0005576	extracellular region	SPRR2A	IDA		Human	PMID:34735226
Cellular Component	GO:0005634	nucleus	Sprr2d	IDA		Mouse	MGI:MGI:3839158|PMID:19301398
Cellular Component	GO:0030141	secretory granule	SPRR2A	IDA		Human	PMID:34735226
Biological Process	GO:0019731	antibacterial humoral response	SPRR2A	IDA		Human	PMID:34735226
Biological Process	GO:0050830	defense response to Gram-positive bacterium	SPRR2A	IDA		Human	PMID:34735226
Biological Process	GO:0008585	female gonad development	Sprr2d	IEP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:0018149	peptide cross-linking	SPRR2E	IDA		Human	PMID:7543090
Biological Process	GO:0018149	peptide cross-linking	SPRR2E	IDA		Human	PMID:9722562
Biological Process	GO:0032355	response to estradiol	Sprr2d	IDA		Mouse	PMID:15232223

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern