Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC12A1
  • Mouse genes Slc12a1
  • Rat genes Slc12a1
  • Zfish genes slc12a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc12a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Slc12a1	IPI	PR:Q6P9R2	Mouse	PMID:12386165
Molecular Function	GO:0005515	protein binding	Slc12a1	IPI	PR:Q9Z1W9	Mouse	PMID:12386165
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	Slc12a1	IDA		Mouse	MGI:MGI:2177364|PMID:11790783
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	Slc12a1	IDA		Rat	PMID:16291577|RGD:1624189
Cellular Component	GO:0016324	apical plasma membrane	Slc12a1	IDA		Mouse	MGI:MGI:6381273|PMID:29993276
Cellular Component	GO:0016324	apical plasma membrane	Slc12a1	IDA		Mouse	PMID:15550389
Cellular Component	GO:0016324	apical plasma membrane	Slc12a1	IDA		Mouse	PMID:11423561
Cellular Component	GO:0016324	apical plasma membrane	Slc12a1	IDA		Rat	PMID:19592485|RGD:7242914
Cellular Component	GO:0016324	apical plasma membrane	slc12a1	IDA		Zfish	PMID:19633174
Cellular Component	GO:0009986	cell surface	Slc12a1	IDA		Rat	PMID:19592485|RGD:7242914
Cellular Component	GO:0070062	extracellular exosome	SLC12A1	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	SLC12A1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SLC12A1	IDA		Human	PMID:21082674
Cellular Component	GO:0070062	extracellular exosome	SLC12A1	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	Slc12a1	IDA		Rat	PMID:16291577|RGD:1624189
Biological Process	GO:0006821	chloride transport	Slc12a1	IDA		Rat	PMID:16291577|RGD:1624189
Biological Process	GO:0016101	diterpenoid metabolic process	Slc12a1	IEP		Rat	PMID:19592485|RGD:7242914
Biological Process	GO:0001822	kidney development	Slc12a1	IMP	MGI:MGI:3712283	Mouse	PMID:17264314
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Slc12a1	IDA		Rat	PMID:16275913|RGD:8553410
Biological Process	GO:0006813	potassium ion transport	Slc12a1	IDA		Rat	PMID:16291577|RGD:1624189
Biological Process	GO:0032978	protein insertion into membrane from inner side	Slc12a1	IDA		Rat	PMID:19592485|RGD:7242914
Biological Process	GO:0006814	sodium ion transport	Slc12a1	IDA		Rat	PMID:16291577|RGD:1624189
Biological Process	GO:0071918	urea transmembrane transport	Slc12a1	IMP	MGI:MGI:3712283	Mouse	PMID:17264314

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern