Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIM2
  • Mouse genes Sim2
  • Rat genes Sim2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sim2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sim2	IDA		Mouse	PMID:11782478
Molecular Function	GO:0005515	protein binding	Sim2	IPI	PR:P53762	Mouse	PMID:11782478
Molecular Function	GO:0046982	protein heterodimerization activity	Sim2	IPI	UniProtKB:Q61324	Mouse	MGI:MGI:82794|PMID:8927054
Cellular Component	GO:0016604	nuclear body	SIM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Sim2	IDA		Mouse	PMID:11782478
Biological Process	GO:0009880	embryonic pattern specification	Sim2	IMP	MGI:MGI:2180881	Mouse	PMID:12024028
Biological Process	GO:0030324	lung development	Sim2	IMP	MGI:MGI:2180881	Mouse	PMID:12024028
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sim2	IDA		Mouse	PMID:11782478
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sim2	IGI	MGI:MGI:2664186	Mouse	PMID:14701734

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern