Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH2D1A
  • Mouse genes Sh2d1a
  • Rat genes Sh2d1a
  • Zfish genes sh2d1aa,sh2d1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh2d1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:10549287
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:11389028
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:11477068
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96DU3	Human	PMID:11489943
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9BZW8	Human	PMID:11489943
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:11806999
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:11823424
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:12225753
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:12545174
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:14674764
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96DU3	Human	PMID:16920955
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9BZW8	Human	PMID:16920955
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:20231852
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:P20963	Human	PMID:22912825
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96DU3	Human	PMID:22912825
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96DU3	Human	PMID:23346089
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9BZW8	Human	PMID:23346089
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9BZW8	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96DU3	Human	PMID:24688028
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q07912	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q969G2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q07912-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q969G2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9BZW8	Human	PMID:26221972
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q9UBR4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:P01100	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:P12931	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SH2D1A	IPI	UniProtKB:Q13291	Human	PMID:9774102
Molecular Function	GO:0005515	protein binding	Sh2d1a	IPI	UniProtKB:Q9QUM4	Mouse	MGI:MGI:3653974|PMID:16847311
Molecular Function	GO:0005515	protein binding	Sh2d1a	IPI	UniProtKB:Q9QUM4	Mouse	MGI:MGI:3836377|PMID:19151721
Molecular Function	GO:0005515	protein binding	Sh2d1a	IPI	PR:Q9QUM4	Mouse	PMID:10970095
Cellular Component	GO:0005737	cytoplasm	SH2D1A	IDA		Human	PMID:9774102
Biological Process	GO:0006959	humoral immune response	Sh2d1a	IMP	MGI:MGI:2388241	Mouse	PMID:12529646
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1a	IGI	MGI:MGI:3622649	Mouse	PMID:19648922
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1a	IMP	MGI:MGI:3575311	Mouse	PMID:16127454
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1a	IGI	MGI:MGI:1349420	Mouse	PMID:19648922
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	SH2D1A	IDA		Human	PMID:9774102
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1a	IMP	MGI:MGI:3575311	Mouse	PMID:16127454
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1a	IGI	MGI:MGI:3622649	Mouse	PMID:19648922
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1a	IGI	MGI:MGI:1349420	Mouse	PMID:19648922
Biological Process	GO:0050776	regulation of immune response	SH2D1A	IMP		Human	PMID:9774102

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern