Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH2B1
  • Mouse genes Sh2b1
  • Rat genes Sh2b1
  • Zfish genes sh2b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh2b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P42227	Human	PMID:24396070
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P00533	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SH2B1	IPI	UniProtKB:P06213	Human	PMID:9742218
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	UniProtKB:P05622	Mouse	MGI:MGI:5009204|PMID:10644978
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	UniProtKB:Q62120	Mouse	MGI:MGI:5508631|PMID:16824542
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	UniProtKB:Q62120	Mouse	MGI:MGI:5508275|PMID:15121872
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	UniProtKB:P07949	Rat	PMID:16569669|RGD:8553961
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	UniProtKB:P07949	Rat	PMID:17471236|RGD:8554590
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	RGD:619814	Rat	PMID:25586189|RGD:11576287
Molecular Function	GO:0005515	protein binding	Sh2b1	IPI	RGD:10823	Rat	PMID:9343427|RGD:633991
Biological Process	GO:0030032	lamellipodium assembly	Sh2b1	IDA		Mouse	PMID:11786545
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Sh2b1	IDA		Mouse	MGI:MGI:5009204|PMID:10644978
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	SH2B1	IGI	UniProtKB:Q5VV43	Human	PMID:28334068
Biological Process	GO:2000278	regulation of DNA biosynthetic process	Sh2b1	IMP		Mouse	MGI:MGI:5009204|PMID:10644978

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern