Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN4A
  • Mouse genes Scn4a
  • Rat genes Scn4a
  • Zfish genes scn4aa,scn4ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCN4A	IPI	UniProtKB:Q07699	Human	PMID:30190309
Molecular Function	GO:0005515	protein binding	SCN4A	IPI	UniProtKB:Q07699-1	Human	PMID:30190309
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN4A	IDA		Human	PMID:12766226
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN4A	IDA		Human	PMID:30190309
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn4a	IDA		Mouse	PMID:11834499
Cellular Component	GO:0005886	plasma membrane	SCN4A	IDA		Human	PMID:12766226
Cellular Component	GO:0005886	plasma membrane	SCN4A	IDA		Human	PMID:30190309
Cellular Component	GO:0005886	plasma membrane	Scn4a	IDA		Rat	PMID:16303569|RGD:13825437
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN4A	IDA		Human	PMID:30190309
Biological Process	GO:0015871	choline transport	Scn4a	IMP		Rat	PMID:20926383|RGD:7243169
Biological Process	GO:0006812	monoatomic cation transport	Scn4a	IMP		Rat	PMID:20926383|RGD:7243169
Biological Process	GO:0006813	potassium ion transport	Scn4a	IMP		Rat	PMID:20926383|RGD:7243169
Biological Process	GO:0100001	regulation of skeletal muscle contraction by action potential	SCN4A	IMP		Human	PMID:12766226
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN4A	IDA		Human	PMID:12766226
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN4A	IDA		Human	PMID:30190309
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn4a	IDA		Mouse	MGI:MGI:3623302|PMID:11834499
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn4a	IDA		Rat	PMID:16303569|RGD:13825437
Biological Process	GO:0006814	sodium ion transport	Scn4a	IDA		Mouse	PMID:11834499
Biological Process	GO:0006814	sodium ion transport	Scn4a	IDA		Rat	PMID:20926383|RGD:7243169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern