Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCLY
  • Mouse genes Scly
  • Rat genes Scly
  • Zfish genes scly
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scly

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Scly	IDA		Rat	PMID:20164179|RGD:12793035
Molecular Function	GO:0005515	protein binding	SCLY	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	SCLY	IPI	UniProtKB:Q8N448	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SCLY	IPI	UniProtKB:Q8N448	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	SCLY	IPI	UniProtKB:Q8N448	Human	PMID:31515488
Molecular Function	GO:0042803	protein homodimerization activity	Scly	IDA		Rat	PMID:20164179|RGD:12793035
Molecular Function	GO:0009000	selenocysteine lyase activity	Scly	IMP		Rat	PMID:20164179|RGD:12793035
Molecular Function	GO:0070279	vitamin B6 binding	Scly	IDA		Rat	PMID:20164179|RGD:12793035
Cellular Component	GO:1902494	catalytic complex	Scly	IDA		Rat	PMID:20164179|RGD:12793035
Cellular Component	GO:0005794	Golgi apparatus	SCLY	IDA		Human	GO_REF:0000052
Biological Process	GO:0006629	lipid metabolic process	Scly	IMP	MGI:MGI:4362224	Mouse	PMID:22890841
Biological Process	GO:1900408	negative regulation of cellular response to oxidative stress	Scly	IMP	MGI:MGI:4362224	Mouse	PMID:22890841
Biological Process	GO:0032868	response to insulin	Scly	IMP	MGI:MGI:4362224	Mouse	PMID:22890841
Biological Process	GO:0001887	selenium compound metabolic process	Scly	IMP	MGI:MGI:4362224	Mouse	PMID:22890841
Biological Process	GO:0016261	selenocysteine catabolic process	Scly	IMP		Rat	PMID:20164179|RGD:12793035

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern