Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRRT2
  • Mouse genes Prrt2
  • Rat genes Prrt2
  • Zfish genes prrt2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prrt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q71RC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRRT2	IPI	UniProtKB:Q9NZD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Prrt2	IPI	UniProtKB:O35526|UniProtKB:P60879	Mouse	MGI:MGI:6114881|PMID:29056747
Molecular Function	GO:0005515	protein binding	Prrt2	IPI	UniProtKB:P46096|UniProtKB:P46097|UniProtKB:P60879	Mouse	MGI:MGI:5792766|PMID:27052163
Molecular Function	GO:0017124	SH3 domain binding	Prrt2	IDA		Rat	PMID:26797119|RGD:11528976
Molecular Function	GO:0017075	syntaxin-1 binding	Prrt2	IDA		Mouse	MGI:MGI:6114881|PMID:29056747
Cellular Component	GO:0043679	axon terminus	Prrt2	IDA		Mouse	MGI:MGI:6114881|PMID:29056747
Cellular Component	GO:0098978	glutamatergic synapse	Prrt2	IDA		Mouse	PMID:27052163
Cellular Component	GO:0098978	glutamatergic synapse	Prrt2	IPI		Mouse	PMID:27052163
Cellular Component	GO:0098978	glutamatergic synapse	Prrt2	IMP		Mouse	PMID:27052163
Cellular Component	GO:0016020	membrane	Prrt2	IDA		Mouse	PMID:22101681
Cellular Component	GO:0043005	neuron projection	Prrt2	IDA		Rat	PMID:26797119|RGD:11528976
Cellular Component	GO:0005886	plasma membrane	PRRT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Prrt2	IDA		Mouse	PMID:26797119
Cellular Component	GO:0098793	presynapse	Prrt2	IDA		Mouse	MGI:MGI:5792766|PMID:27052163
Cellular Component	GO:0098793	presynapse	Prrt2	IDA		Mouse	MGI:MGI:6114881|PMID:29056747
Cellular Component	GO:0042734	presynaptic membrane	Prrt2	IDA		Mouse	PMID:27052163
Cellular Component	GO:0042734	presynaptic membrane	Prrt2	IMP		Mouse	PMID:27052163
Cellular Component	GO:0042734	presynaptic membrane	Prrt2	IEP		Mouse	PMID:27052163
Cellular Component	GO:0042734	presynaptic membrane	Prrt2	IDA		Mouse	PMID:29056747
Cellular Component	GO:0042734	presynaptic membrane	Prrt2	IEP		Mouse	PMID:29056747
Cellular Component	GO:0008021	synaptic vesicle	Prrt2	IDA		Mouse	MGI:MGI:5792766|PMID:27052163
Cellular Component	GO:0031982	vesicle	Prrt2	IDA		Mouse	MGI:MGI:6114881|PMID:29056747
Biological Process	GO:1905513	negative regulation of short-term synaptic potentiation	Prrt2	IMP		Mouse	MGI:MGI:6114881|PMID:29056747
Biological Process	GO:0035544	negative regulation of SNARE complex assembly	Prrt2	IMP		Mouse	MGI:MGI:6114881|PMID:29056747
Biological Process	GO:0050884	neuromuscular process controlling posture	PRRT2	IMP		Human	PMID:22101681
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Prrt2	IMP		Mouse	PMID:27052163
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Prrt2	IDA		Mouse	PMID:27052163
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Prrt2	IPI		Mouse	PMID:27052163
Biological Process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	Prrt2	IMP		Mouse	MGI:MGI:5792766|PMID:27052163

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern