Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLR1A
  • Mouse genes Polr1a
  • Rat genes Polr1a
  • Zfish genes polr1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Polr1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	POLR1A	IDA		Human	PMID:26089203
Molecular Function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Polr1a	IDA		Rat	PMID:9422795|RGD:2312782
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q9H9Y6	Human	PMID:16514417
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q9H9Y6	Human	PMID:19214185
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:P04626	Human	PMID:21555369
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q96FC9	Human	PMID:26089203
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q9H9Y6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLR1A	IPI	UniProtKB:Q96IM9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Polr1a	IPI	PR:P97304	Mouse	PMID:15226435
Molecular Function	GO:0005515	protein binding	Polr1a	IPI	PR:Q76KJ5	Mouse	PMID:15226435
Molecular Function	GO:0005515	protein binding	Polr1a	IPI	PR:P70700	Mouse	PMID:9236775
Molecular Function	GO:0001054	RNA polymerase I activity	POLR1A	IMP		Human	PMID:23782956
Cellular Component	GO:0005694	chromosome	Polr1a	IDA		Mouse	MGI:MGI:6272683|PMID:30272023
Cellular Component	GO:0005694	chromosome	Polr1a	IDA		Mouse	MGI:MGI:6478065|PMID:30746471
Cellular Component	GO:0005634	nucleus	Polr1a	IDA		Mouse	PMID:9236775
Cellular Component	GO:0005736	RNA polymerase I complex	Polr1a	IDA		Mouse	PMID:9236775
Cellular Component	GO:0005736	RNA polymerase I complex	Polr1a	IDA		Mouse	PMID:15226435
Cellular Component	GO:0005736	RNA polymerase I complex	Polr1a	IDA		Rat	PMID:9422795|RGD:2312782
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	polr1a	IMP	ZFIN:ZDB-GENO-150623-3	Zfish	PMID:25913037
Biological Process	GO:1904750	negative regulation of protein localization to nucleolus	POLR1A	IMP		Human	PMID:23782956
Biological Process	GO:0014032	neural crest cell development	polr1a	IMP	ZFIN:ZDB-GENO-150623-3	Zfish	PMID:25913037
Biological Process	GO:0009303	rRNA transcription	Polr1a	IDA		Rat	PMID:9422795|RGD:2312782
Biological Process	GO:0009303	rRNA transcription	polr1a	IMP	ZFIN:ZDB-GENO-150623-3	Zfish	PMID:29750247

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern