Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLA2
  • Mouse genes Pola2
  • Rat genes Pola2
  • Zfish genes pola2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pola2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola2	IMP		Rat	PMID:11536367|RGD:633584
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola2	IMP		Rat	PMID:7503737|RGD:2307013
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:O75460-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P31948	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P49591	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P54652	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:Q0VDC6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	POLA2	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pola2	IPI	UniProtKB:P33609	Mouse	MGI:MGI:3687659|PMID:10523676
Molecular Function	GO:0005515	protein binding	Pola2	IPI	PR:P33609	Mouse	PMID:9584195
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA2	IPI		Human	PMID:26975377
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA2	IDA		Human	PMID:22465957
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA2	IDA		Human	PMID:26975377
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA2	IDA		Human	PMID:8026492
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola2	IPI		Mouse	MGI:MGI:3687659|PMID:10523676
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola2	IDA		Mouse	MGI:MGI:6478526|PMID:8026492
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola2	IDA		Mouse	PMID:9584195
Cellular Component	GO:0005829	cytosol	POLA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	POLA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Pola2	IDA		Mouse	PMID:9584195
Biological Process	GO:0008283	cell population proliferation	pola2	IMP	ZFIN:ZDB-GENO-210114-1	Zfish	PMID:31786062
Biological Process	GO:0006260	DNA replication	Pola2	IDA		Mouse	PMID:9584195
Biological Process	GO:0006260	DNA replication	Pola2	IMP		Rat	PMID:7503737|RGD:2307013
Biological Process	GO:0006270	DNA replication initiation	POLA2	IDA		Human	PMID:26975377
Biological Process	GO:0006270	DNA replication initiation	Pola2	IDA		Mouse	MGI:MGI:3687659|PMID:10523676
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	POLA2	IDA		Human	PMID:8026492
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	Pola2	IDA		Mouse	MGI:MGI:6478526|PMID:8026492
Biological Process	GO:0031101	fin regeneration	pola2	IMP	ZFIN:ZDB-GENO-210114-1	Zfish	PMID:31786062
Biological Process	GO:0006606	protein import into nucleus	Pola2	IDA		Mouse	PMID:9584195

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern