Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEKHH2
  • Mouse genes Plekhh2
  • Rat genes Plekhh2
  • Zfish genes plekhh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plekhh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Plekhh2	IDA		Mouse	MGI:MGI:5487756|PMID:22832517
Molecular Function	GO:0005515	protein binding	PLEKHH2	IPI	UniProtKB:O60711	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLEKHH2	IPI	UniProtKB:O60711	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Plekhh2	IPI	UniProtKB:Q62219	Mouse	MGI:MGI:5487756|PMID:22832517
Cellular Component	GO:0030864	cortical actin cytoskeleton	Plekhh2	IDA		Mouse	MGI:MGI:5487756|PMID:22832517
Cellular Component	GO:0005737	cytoplasm	PLEKHH2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	PLEKHH2	IDA		Human	PMID:22832517
Cellular Component	GO:0005829	cytosol	PLEKHH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	PLEKHH2	IDA		Human	PMID:22832517
Cellular Component	GO:0016604	nuclear body	PLEKHH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PLEKHH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PLEKHH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PLEKHH2	IDA		Human	PMID:22832517
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	Plekhh2	IDA		Mouse	MGI:MGI:5487756|PMID:22832517

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern