Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDHA1
  • Mouse genes Pdha1
  • Rat genes Pdha1,Pdha1l1
  • Zfish genes pdha1a,pdha1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdha1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PDHA1	IPI	UniProtKB:P11177	Human	PMID:12651851
Molecular Function	GO:0005515	protein binding	PDHA1	IPI	UniProtKB:P11177	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PDHA1	IPI	UniProtKB:Q16891	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	PDHA1	IPI	UniProtKB:Q15118	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	PDHA1	IPI	UniProtKB:Q15118	Human	PMID:7782287
Molecular Function	GO:0005515	protein binding	Pdha1	IPI	UniProtKB:Q9QXS1	Mouse	MGI:MGI:6189615|PMID:29128334
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	PDHA1	IDA		Human	PMID:19081061
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Pdha1	IDA		Rat	PMID:7487891|RGD:1599112
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	Pdha1	IMP	MGI:MGI:2182095,MGI:MGI:2386703	Mouse	PMID:18586888
Molecular Function	GO:0004738	pyruvate dehydrogenase activity	Pdha1	IMP	MGI:MGI:2386704	Mouse	PMID:11708858
Cellular Component	GO:1902494	catalytic complex	Pdha1	IMP	MGI:MGI:2386704	Mouse	PMID:11708858
Cellular Component	GO:1902494	catalytic complex	Pdha1	IMP	MGI:MGI:2386703	Mouse	PMID:17314311
Cellular Component	GO:1902494	catalytic complex	Pdha1	IMP	MGI:MGI:2386703	Mouse	PMID:15569252
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	PDHA1	IPI		Human	PMID:19240034
Cellular Component	GO:0005739	mitochondrion	PDHA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	PDHA1	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Pdha1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pdha1	IDA		Mouse	PMID:28376086
Cellular Component	GO:0005739	mitochondrion	Pdha1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdha1	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0043209	myelin sheath	Pdha1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005730	nucleolus	PDHA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PDHA1	HDA		Human	PMID:21630459
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	PDHA1	IDA		Human	PMID:19081061
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdha1	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	PDHA1	IDA		Human	PMID:19081061
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	PDHA1	IDA		Human	PMID:24534072
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Pdha1	IMP	MGI:MGI:2182095,MGI:MGI:2386703	Mouse	PMID:18586888
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Pdha1	IDA		Rat	PMID:7487891|RGD:1599112

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern