Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPHS2
  • Mouse genes Nphs2
  • Rat genes Nphs2
  • Zfish genes nphs2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nphs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NPHS2	IPI	UniProtKB:Q8IZU9	Human	PMID:12424224
Molecular Function	GO:0005515	protein binding	NPHS2	IPI	UniProtKB:P78310	Human	PMID:17675666
Molecular Function	GO:0005515	protein binding	NPHS2	IPI	UniProtKB:P46940	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	Nphs2	IPI	PR:Q61143	Mouse	PMID:15924139
Molecular Function	GO:0005515	protein binding	Nphs2	IPI	PR:Q9QZS7	Mouse	PMID:11733557
Molecular Function	GO:0005515	protein binding	Nphs2	IPI	PR:Q9JLQ0	Mouse	PMID:11733557
Molecular Function	GO:0005515	protein binding	nphs2	IPI	ZFIN:ZDB-GENE-051102-1	Zfish	PMID:24337247
Cellular Component	GO:0005911	cell-cell junction	NPHS2	IDA		Human	PMID:17675666
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	NPHS2	IDA		Human	PMID:11786407
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Nphs2	IDA		Mouse	MGI:MGI:5426782|PMID:11786407
Cellular Component	GO:0070062	extracellular exosome	NPHS2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	NPHS2	HDA		Human	PMID:23533145
Cellular Component	GO:0045121	membrane raft	NPHS2	IDA		Human	PMID:17675666
Cellular Component	GO:0005886	plasma membrane	Nphs2	IDA		Mouse	PMID:15924139
Cellular Component	GO:0005886	plasma membrane	Nphs2	IDA		Mouse	PMID:11733557
Cellular Component	GO:0032991	protein-containing complex	NPHS2	IDA		Human	PMID:17675666
Cellular Component	GO:0036057	slit diaphragm	NPHS2	IDA		Human	PMID:11786407
Cellular Component	GO:0036057	slit diaphragm	Nphs2	IDA		Mouse	MGI:MGI:5426782|PMID:11786407
Biological Process	GO:0031532	actin cytoskeleton reorganization	NPHS2	IDA		Human	PMID:17675666
Biological Process	GO:0032835	glomerulus development	nphs2	IMP	ZFIN:ZDB-MRPHLNO-071113-2	Zfish	PMID:17699558
Biological Process	GO:0001822	kidney development	nphs2	IMP	ZFIN:ZDB-MRPHLNO-051102-2	Zfish	PMID:16102746
Biological Process	GO:0072249	metanephric podocyte development	NPHS2	IEP		Human	PMID:11786407
Biological Process	GO:0039021	pronephric glomerulus development	nphs2	IMP	ZFIN:ZDB-MRPHLNO-140522-6	Zfish	PMID:24337247
Biological Process	GO:0039021	pronephric glomerulus development	nphs2	IGI	RefSeq:NM_014625.2,ZFIN:ZDB-MRPHLNO-140522-6	Zfish	PMID:24337247
Biological Process	GO:0039021	pronephric glomerulus development	nphs2	IMP		Zfish	PMID:25556170

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern