Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRX1
  • Mouse genes Nlrx1
  • Rat genes Nlrx1
  • Zfish genes nlrx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NLRX1	IPI	UniProtKB:Q6PDS3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	NLRX1	IPI	UniProtKB:P49411	Human	PMID:28611246
Molecular Function	GO:0005515	protein binding	Nlrx1	IPI	PR:P70196	Mouse	PMID:21703540
Cellular Component	GO:0005739	mitochondrion	NLRX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Nlrx1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005886	plasma membrane	NLRX1	IDA		Human	GO_REF:0000052
Biological Process	GO:0032608	interferon-beta production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0032635	interleukin-6 production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0010934	macrophage cytokine production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0050728	negative regulation of inflammatory response	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0045824	negative regulation of innate immune response	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0032688	negative regulation of interferon-beta production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	Nlrx1	IMP	MGI:MGI:5141085	Mouse	PMID:21703540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern