Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRP2,NLRP7
  • Mouse genes Nlrp2
  • Rat genes Nlrp2
  • Zfish genes si:ch73-168d20.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	NLRP7	IDA		Human	PMID:15817483
Molecular Function	GO:0089720	caspase binding	NLRP7	IPI	UniProtKB:P29466	Human	PMID:15817483
Molecular Function	GO:0019966	interleukin-1 binding	NLRP7	IPI	UniProtKB:P01584	Human	PMID:15817483
Molecular Function	GO:0005515	protein binding	NLRP2	IPI	UniProtKB:Q9Y2G2	Human	PMID:15030775
Molecular Function	GO:0005515	protein binding	NLRP2	IPI	UniProtKB:Q56P42	Human	PMID:17178784
Molecular Function	GO:0032090	Pyrin domain binding	NLRP2	IPI	UniProtKB:Q9ULZ3	Human	PMID:15030775
Cellular Component	GO:0000781	chromosome, telomeric region	NLRP2	IDA		Human	PMID:24270157
Cellular Component	GO:0005737	cytoplasm	NLRP2	IDA		Human	PMID:15030775
Cellular Component	GO:0005829	cytosol	NLRP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	NLRP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NLRP2	IDA		Human	GO_REF:0000052
Biological Process	GO:0071347	cellular response to interleukin-1	NLRP7	IEP		Human	PMID:15817483
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NLRP7	IEP		Human	PMID:15817483
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	NLRP7	IMP		Human	PMID:15817483
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	NLRP7	IMP		Human	PMID:15817483
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	NLRP2	IGI	UniProtKB:Q96P20,UniProtKB:Q9ULZ3	Human	PMID:15817483
Biological Process	GO:0010955	negative regulation of protein processing	NLRP7	IDA		Human	PMID:15817483
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	NLRP2	IDA		Human	PMID:15030775
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP2	IDA		Human	PMID:15030775

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern