Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKD2
  • Mouse genes Nkd2
  • Rat genes Nkd2
  • Zfish genes nkd2a,nkd2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	NKD2	IPI	UniProtKB:P05023	Human	PMID:18504258
Molecular Function	GO:0019838	growth factor binding	NKD2	IPI	UniProtKB:P01135	Human	PMID:15064403
Molecular Function	GO:0060090	molecular adaptor activity	NKD2	EXP		Human	PMID:17045239
Molecular Function	GO:0032036	myosin heavy chain binding	NKD2	IPI	UniProtKB:P35579	Human	PMID:18504258
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:P01135	Human	PMID:15064403
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:Q06190-2	Human	PMID:15687260
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:P01135	Human	PMID:18757723
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:Q96BH1	Human	PMID:18757723
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:O14640	Human	PMID:20177058
Molecular Function	GO:0005515	protein binding	NKD2	IPI	UniProtKB:Q96PM5	Human	PMID:21988832
Molecular Function	GO:0031625	ubiquitin protein ligase binding	NKD2	IPI	UniProtKB:Q9QZR0	Human	PMID:18757723
Cellular Component	GO:0016323	basolateral plasma membrane	NKD2	IDA		Human	PMID:17553928
Cellular Component	GO:0071944	cell periphery	NKD2	IDA		Human	PMID:15064403
Cellular Component	GO:0031410	cytoplasmic vesicle	NKD2	IDA		Human	PMID:15064403
Cellular Component	GO:0070382	exocytic vesicle	NKD2	IDA		Human	PMID:18504258
Cellular Component	GO:0016328	lateral plasma membrane	NKD2	IDA		Human	PMID:20177058
Cellular Component	GO:0005886	plasma membrane	NKD2	IDA		Human	PMID:18504258
Biological Process	GO:0048210	Golgi vesicle fusion to target membrane	NKD2	IMP		Human	PMID:17553928
Biological Process	GO:0070121	Kupffer's vesicle development	nkd2a	IMP	ZFIN:ZDB-MRPHLNO-071203-6	Zfish	PMID:20858476
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	NKD2	IMP		Human	PMID:15687260
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	NKD2	IDA		Human	PMID:20177058
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	nkd2a	IGI	ZFIN:ZDB-GENE-980526-332	Zfish	PMID:20177058
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	NKD2	IMP		Human	PMID:20177058
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	NKD2	IDA		Human	PMID:15064403
Biological Process	GO:0010954	positive regulation of protein processing	NKD2	IDA		Human	PMID:15064403
Biological Process	GO:0072659	protein localization to plasma membrane	NKD2	IMP		Human	PMID:17553928
Biological Process	GO:0060061	Spemann organizer formation	nkd2a	IMP	ZFIN:ZDB-MRPHLNO-071203-7	Zfish	PMID:17689523
Biological Process	GO:0060061	Spemann organizer formation	nkd2a	IMP	ZFIN:ZDB-MRPHLNO-071203-6	Zfish	PMID:17689523
Biological Process	GO:0016055	Wnt signaling pathway	nkd2a	IGI	ZFIN:ZDB-GENE-990603-12	Zfish	PMID:17689523
Biological Process	GO:0016055	Wnt signaling pathway	nkd2a	IGI	ZFIN:ZDB-GENE-980526-332	Zfish	PMID:17689523

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern