Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTERF1,MTHFS
  • Mouse genes Mthfs
  • Rat genes Mthfs
  • Zfish genes mthfs
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mthfs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	MTHFS	IMP		Human	PMID:12764149
Molecular Function	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	MTHFS	IDA		Human	PMID:19738041
Molecular Function	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	MTHFS	IDA		Human	PMID:7766710
Molecular Function	GO:0005524	ATP binding	MTHFS	IDA		Human	PMID:19738041
Molecular Function	GO:0003690	double-stranded DNA binding	MTERF1	IDA		Human	PMID:20550934
Molecular Function	GO:0005542	folic acid binding	MTHFS	IDA		Human	PMID:19738041
Molecular Function	GO:0005542	folic acid binding	MTHFS	IDA		Human	PMID:7766710
Molecular Function	GO:0005515	protein binding	MTERF1	IPI	UniProtKB:Q5F1R6	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	MTERF1	IPI	UniProtKB:Q5BJH2-2	Human	PMID:32296183
Molecular Function	GO:0003723	RNA binding	MTERF1	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	MTHFS	IDA		Human	PMID:7766710
Cellular Component	GO:0005829	cytosol	MTHFS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005759	mitochondrial matrix	MTHFS	IDA		Human	PMID:7766710
Cellular Component	GO:0042645	mitochondrial nucleoid	MTERF1	IDA		Human	PMID:18063578
Cellular Component	GO:0005739	mitochondrion	MTERF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Mthfs	HDA		Mouse	PMID:18614015
Biological Process	GO:0032392	DNA geometric change	MTERF1	IDA		Human	PMID:20550934
Biological Process	GO:0006353	DNA-templated transcription termination	MTERF1	IDA		Human	PMID:20550934
Biological Process	GO:0046657	folic acid catabolic process	MTHFS	IMP		Human	PMID:12764149
Biological Process	GO:0006536	glutamate metabolic process	MTHFS	IMP		Human	PMID:12764149
Biological Process	GO:0006393	termination of mitochondrial transcription	MTERF1	IDA		Human	PMID:20550934
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFS	IMP		Human	PMID:12764149
Biological Process	GO:0046653	tetrahydrofolate metabolic process	MTHFS	IDA		Human	PMID:19738041
Biological Process	GO:0046653	tetrahydrofolate metabolic process	MTHFS	IDA		Human	PMID:7766710

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern