Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTHFD1L
  • Mouse genes Mthfd1l
  • Rat genes Mthfd1l
  • Zfish genes mthfd1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mthfd1l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MTHFD1L	IDA		Human	PMID:16171773
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	MTHFD1L	IDA		Human	PMID:12937168
Molecular Function	GO:0042803	protein homodimerization activity	MTHFD1L	IDA		Human	PMID:16171773
Cellular Component	GO:0016020	membrane	MTHFD1L	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	MTHFD1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	MTHFD1L	IDA		Human	PMID:12937168
Cellular Component	GO:0005739	mitochondrion	Mthfd1l	IDA		Mouse	MGI:MGI:4453089|PMID:19948730
Cellular Component	GO:0005739	mitochondrion	Mthfd1l	HDA		Mouse	PMID:18614015
Biological Process	GO:0009257	10-formyltetrahydrofolate biosynthetic process	MTHFD1L	IDA		Human	PMID:12937168
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	Mthfd1l	IMP		Mouse	MGI:MGI:5468075|PMID:23267094
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	Mthfd1l	IMP		Mouse	MGI:MGI:5468075|PMID:23267094
Biological Process	GO:0006760	folic acid-containing compound metabolic process	MTHFD1L	IDA		Human	PMID:12937168
Biological Process	GO:0015942	formate metabolic process	MTHFD1L	IDA		Human	PMID:16171773
Biological Process	GO:0001843	neural tube closure	Mthfd1l	IMP		Mouse	MGI:MGI:5468075|PMID:23267094

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern