Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MTHFD1
  • Mouse genes Mthfd1
  • Rat genes Mthfd1,Mthfd1-ps1
  • Zfish genes mthfd1a,mthfd1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mthfd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	MTHFD1	IDA		Human	PMID:18767138
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	MTHFD1	IDA		Human	PMID:1881876
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity	Mthfd1	IMP		Mouse	MGI:MGI:3575047|PMID:15611115
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	MTHFD1	IDA		Human	PMID:10828945
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	MTHFD1	IDA		Human	PMID:1881876
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Mthfd1	IDA		Mouse	MGI:MGI:5503248|PMID:23704330
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	MTHFD1	IDA		Human	PMID:10828945
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	MTHFD1	IDA		Human	PMID:18767138
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Mthfd1	IMP		Mouse	MGI:MGI:3575047|PMID:15611115
Molecular Function	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	MTHFD1	IDA		Human	PMID:1881876
Molecular Function	GO:0005515	protein binding	MTHFD1	IPI	UniProtKB:Q9WMX2	Human	PMID:24169621
Cellular Component	GO:0070062	extracellular exosome	MTHFD1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MTHFD1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	MTHFD1	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	MTHFD1	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Mthfd1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Mthfd1	HDA		Mouse	PMID:14651853
Biological Process	GO:0009257	10-formyltetrahydrofolate biosynthetic process	MTHFD1	IDA		Human	PMID:1881876
Biological Process	GO:0009257	10-formyltetrahydrofolate biosynthetic process	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0007507	heart development	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0009086	methionine biosynthetic process	MTHFD1	IMP		Human	PMID:25633902
Biological Process	GO:0006555	methionine metabolic process	Mthfd1	IMP		Mouse	MGI:MGI:5621260|PMID:23190757
Biological Process	GO:0001843	neural tube closure	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0001780	neutrophil homeostasis	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0009117	nucleotide metabolic process	Mthfd1	IEP		Rat	PMID:14597174|RGD:1302361
Biological Process	GO:0006730	one-carbon metabolic process	MTHFD1	IMP		Human	PMID:25633902
Biological Process	GO:0006730	one-carbon metabolic process	Mthfd1	IEP		Rat	PMID:14597174|RGD:1302361
Biological Process	GO:0006164	purine nucleotide biosynthetic process	MTHFD1	IMP		Human	PMID:18767138
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0009152	purine ribonucleotide biosynthetic process	Mthfd1	IMP		Mouse	MGI:MGI:3575047|PMID:15611115
Biological Process	GO:0035713	response to nitrogen dioxide	Mthfd1	IEP		Rat	PMID:3264158|RGD:12914153
Biological Process	GO:0009070	serine family amino acid biosynthetic process	MTHFD1	IMP		Human	PMID:25633902
Biological Process	GO:0009069	serine family amino acid metabolic process	Mthfd1	IMP		Mouse	MGI:MGI:5621260|PMID:23190757
Biological Process	GO:0061053	somite development	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFD1	IDA		Human	PMID:10828945
Biological Process	GO:0035999	tetrahydrofolate interconversion	MTHFD1	IDA		Human	PMID:1881876
Biological Process	GO:0035999	tetrahydrofolate interconversion	Mthfd1	IMP		Mouse	MGI:MGI:5503248|PMID:23704330
Biological Process	GO:0019346	transsulfuration	Mthfd1	IMP		Mouse	MGI:MGI:5621260|PMID:23190757

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern