Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MORC2
  • Mouse genes Morc2b
  • Rat genes Morc2b
  • Zfish genes morc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Morc2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MORC2	IDA		Human	PMID:29440755
Molecular Function	GO:0016887	ATP hydrolysis activity	MORC2	IDA		Human	PMID:23260667
Molecular Function	GO:0016887	ATP hydrolysis activity	MORC2	IDA		Human	PMID:29440755
Molecular Function	GO:0003682	chromatin binding	MORC2	IDA		Human	PMID:23260667
Molecular Function	GO:0003682	chromatin binding	MORC2	IDA		Human	PMID:29211708
Molecular Function	GO:0000287	magnesium ion binding	MORC2	IDA		Human	PMID:29440755
Molecular Function	GO:0005515	protein binding	MORC2	IPI	UniProtKB:Q99549,UniProtKB:Q9UK61	Human	PMID:28581500
Molecular Function	GO:0005515	protein binding	Morc2b	IPI	UniProtKB:Q69ZX6	Mouse	MGI:MGI:6115697|PMID:29329290
Molecular Function	GO:0042803	protein homodimerization activity	MORC2	IDA		Human	PMID:29440755
Molecular Function	GO:0008270	zinc ion binding	MORC2	IDA		Human	PMID:29440755
Cellular Component	GO:0005737	cytoplasm	MORC2	IDA		Human	PMID:23260667
Cellular Component	GO:0005829	cytosol	MORC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000792	heterochromatin	MORC2	IDA		Human	PMID:28581500
Cellular Component	GO:0016363	nuclear matrix	MORC2	IDA		Human	PMID:23260667
Cellular Component	GO:0005654	nucleoplasm	MORC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MORC2	IDA		Human	PMID:23260667
Cellular Component	GO:0005634	nucleus	Morc2b	IMP		Mouse	MGI:MGI:6115697|PMID:29329290
Biological Process	GO:0006338	chromatin remodeling	MORC2	IDA		Human	PMID:23260667
Biological Process	GO:0006974	DNA damage response	MORC2	IDA		Human	PMID:23260667
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	Morc2b	IMP		Mouse	MGI:MGI:6115697|PMID:29329290
Biological Process	GO:0007276	gamete generation	Morc2b	IMP		Mouse	MGI:MGI:6115697|PMID:29329290
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Morc2b	IMP		Mouse	MGI:MGI:6115697|PMID:29329290
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MORC2	IDA		Human	PMID:28581500
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	MORC2	IDA		Human	PMID:29211708
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	MORC2	IMP		Human	PMID:29211708
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	MORC2	IDA		Human	PMID:28581500
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	MORC2	IDA		Human	PMID:29211708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern