Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLPH
  • Mouse genes Mlph
  • Rat genes Mlph
  • Zfish genes mlpha,mlphb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlph

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Mlph	IDA		Mouse	PMID:12221080
Molecular Function	GO:0051010	microtubule plus-end binding	Mlph	IDA		Mouse	PMID:16247022
Molecular Function	GO:0051010	microtubule plus-end binding	Mlph	IPI	PR:Q99104	Mouse	PMID:16137617
Molecular Function	GO:0060090	molecular adaptor activity	Mlph	EXP		Mouse	MGI:MGI:5882888|PMID:17513864
Molecular Function	GO:0060090	molecular adaptor activity	Mlph	IDA		Mouse	MGI:MGI:5882888|PMID:17513864
Molecular Function	GO:0017022	myosin binding	MLPH	IPI	UniProtKB:Q9Y4I1	Human	PMID:11980908
Molecular Function	GO:0017022	myosin binding	Mlph	IDA		Mouse	PMID:11856727
Molecular Function	GO:0031489	myosin V binding	Mlph	IPI	UniProtKB:Q99104	Mouse	MGI:MGI:5882888|PMID:17513864
Molecular Function	GO:0031489	myosin V binding	Mlph	IPI	PR:Q99104	Mouse	PMID:14730011
Molecular Function	GO:0031489	myosin V binding	Mlph	IPI	PR:Q99104	Mouse	PMID:11887186
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:P51159-1	Human	PMID:12446441
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:P51159	Human	PMID:12897212
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:P51159	Human	PMID:17045265
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:P51159	Human	PMID:25312756
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:O00194	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:Q6P9E2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:Q8TAB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MLPH	IPI	UniProtKB:Q9UL45	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Mlph	IPI	UniProtKB:Q99P58|UniProtKB:Q9ERI2	Mouse	MGI:MGI:4412434|PMID:18940604
Molecular Function	GO:0005515	protein binding	Mlph	IPI	UniProtKB:Q99P58	Mouse	MGI:MGI:4412434|PMID:18940604
Molecular Function	GO:0005515	protein binding	Mlph	IPI	UniProtKB:Q9ERI2	Mouse	MGI:MGI:2176311|PMID:11773082
Molecular Function	GO:0005515	protein binding	Mlph	IPI	PR:Q61166	Mouse	PMID:16247022
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	MLPH	IPI	UniProtKB:P51159,UniProtKB:Q9Y4I1	Human	PMID:11980908
Molecular Function	GO:0031267	small GTPase binding	MLPH	IPI	UniProtKB:O00194	Human	PMID:15357836
Molecular Function	GO:0031267	small GTPase binding	Mlph	IDA		Mouse	PMID:11856727
Cellular Component	GO:0015629	actin cytoskeleton	Mlph	IDA		Mouse	PMID:12221080
Cellular Component	GO:0030864	cortical actin cytoskeleton	Mlph	IDA		Mouse	PMID:16247022
Cellular Component	GO:0030425	dendrite	MLPH	IDA		Human	PMID:15357836
Cellular Component	GO:0070062	extracellular exosome	MLPH	HDA		Human	PMID:23533145
Cellular Component	GO:0042470	melanosome	Mlph	IDA		Mouse	PMID:16137617
Cellular Component	GO:0042470	melanosome	Mlph	IDA		Mouse	PMID:16247022
Cellular Component	GO:0042470	melanosome	Mlph	IDA		Mouse	PMID:11887186
Cellular Component	GO:0042470	melanosome	Mlph	IDA		Mouse	PMID:14730011
Cellular Component	GO:0005815	microtubule organizing center	Mlph	IDA		Mouse	PMID:16247022
Cellular Component	GO:0048471	perinuclear region of cytoplasm	MLPH	IDA		Human	PMID:15357836
Cellular Component	GO:0001725	stress fiber	Mlph	IDA		Mouse	PMID:16247022
Cellular Component	GO:0016461	unconventional myosin complex	Mlph	IMP		Mouse	MGI:MGI:5882888|PMID:17513864
Biological Process	GO:0030318	melanocyte differentiation	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:11504925
Biological Process	GO:0030318	melanocyte differentiation	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:2379821
Biological Process	GO:0032400	melanosome localization	Mlph	IMP		Mouse	PMID:14730011
Biological Process	GO:0032400	melanosome localization	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:11886590
Biological Process	GO:0032400	melanosome localization	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:11887186
Biological Process	GO:0051876	pigment granule dispersal	mlpha	IMP	ZFIN:ZDB-MRPHLNO-080516-3	Zfish	PMID:17919909
Biological Process	GO:0051876	pigment granule dispersal	mlpha	IMP	ZFIN:ZDB-GENO-080516-1	Zfish	PMID:17919909
Biological Process	GO:0043473	pigmentation	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:17247639
Biological Process	GO:0006605	protein targeting	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:11887186
Biological Process	GO:0006605	protein targeting	Mlph	IMP	MGI:MGI:1856674	Mouse	PMID:11886590

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern