Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLKL
  • Mouse genes Mlkl
  • Rat genes Mlkl
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlkl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MLKL	IDA		Human	PMID:24219132
Molecular Function	GO:0005524	ATP binding	Mlkl	IDA		Mouse	MGI:MGI:5532892|PMID:24012422
Molecular Function	GO:0005515	protein binding	MLKL	IPI	UniProtKB:Q9Y572	Human	PMID:22265413
Molecular Function	GO:0005515	protein binding	MLKL	IPI	UniProtKB:Q9Y572	Human	PMID:22265414
Molecular Function	GO:0005515	protein binding	MLKL	IPI	UniProtKB:Q9Y572	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	Mlkl	IPI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5516182|PMID:22265413
Molecular Function	GO:0005515	protein binding	Mlkl	IPI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:6436434|PMID:27321907
Molecular Function	GO:0005515	protein binding	Mlkl	IPI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5796070|PMID:26559832
Molecular Function	GO:0005515	protein binding	Mlkl	IPI	UniProtKB:Q9QZL0|UniProtKB:U5TQE9	Mouse	MGI:MGI:5796070|PMID:26559832
Molecular Function	GO:0019901	protein kinase binding	Mlkl	IPI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5532892|PMID:24012422
Molecular Function	GO:0019901	protein kinase binding	Mlkl	IPI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5532864|PMID:24095729
Molecular Function	GO:0044877	protein-containing complex binding	MLKL	IDA		Human	PMID:22265414
Cellular Component	GO:0030054	cell junction	MLKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	MLKL	IDA		Human	PMID:24316671
Cellular Component	GO:0005737	cytoplasm	Mlkl	IDA		Mouse	MGI:MGI:6434626|PMID:32296175
Cellular Component	GO:0005737	cytoplasm	Mlkl	IDA		Mouse	MGI:MGI:6436412|PMID:32200799
Cellular Component	GO:0005829	cytosol	MLKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Mlkl	IDA		Mouse	MGI:MGI:6436412|PMID:32200799
Cellular Component	GO:0005634	nucleus	Mlkl	IDA		Mouse	MGI:MGI:6434626|PMID:32296175
Cellular Component	GO:0005886	plasma membrane	MLKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	MLKL	IDA		Human	PMID:24316671
Cellular Component	GO:0005886	plasma membrane	MLKL	IDA		Human	PMID:29883610
Cellular Component	GO:0005886	plasma membrane	Mlkl	IDA		Mouse	MGI:MGI:6436412|PMID:32200799
Biological Process	GO:0051607	defense response to virus	Mlkl	IDA		Mouse	MGI:MGI:6434626|PMID:32296175
Biological Process	GO:0051607	defense response to virus	Mlkl	IMP		Mouse	MGI:MGI:6436434|PMID:27321907
Biological Process	GO:0051607	defense response to virus	Mlkl	IDA		Mouse	MGI:MGI:6436412|PMID:32200799
Biological Process	GO:0097528	execution phase of necroptosis	Mlkl	IDA		Mouse	MGI:MGI:6434626|PMID:32296175
Biological Process	GO:0097528	execution phase of necroptosis	Mlkl	IDA		Mouse	MGI:MGI:6436412|PMID:32200799
Biological Process	GO:0097528	execution phase of necroptosis	Mlkl	IMP		Mouse	MGI:MGI:6436434|PMID:27321907
Biological Process	GO:0070266	necroptotic process	MLKL	IMP		Human	PMID:22265414
Biological Process	GO:0070266	necroptotic process	MLKL	IMP		Human	PMID:24316671
Biological Process	GO:0070266	necroptotic process	MLKL	IMP		Human	PMID:29883610
Biological Process	GO:0070266	necroptotic process	Mlkl	IMP		Mouse	MGI:MGI:5532894|PMID:23835476
Biological Process	GO:0070266	necroptotic process	Mlkl	IMP		Mouse	MGI:MGI:5532892|PMID:24012422
Biological Process	GO:0097527	necroptotic signaling pathway	MLKL	IMP		Human	PMID:22265413
Biological Process	GO:0097527	necroptotic signaling pathway	Mlkl	IMP		Mouse	MGI:MGI:5516182|PMID:22265413
Biological Process	GO:0070207	protein homotrimerization	MLKL	IDA		Human	PMID:24316671

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern