Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mettl3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes METTL3
- Mouse genes Mettl3
- Rat genes Mettl3
- Zfish genes mettl3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mettl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	mettl3	IMP	ZFIN:ZDB-GENO-180410-6	Zfish	PMID:29196300
Molecular Function	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	mettl3	IMP	ZFIN:ZDB-GENO-180410-3	Zfish	PMID:29196300
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IMP		Human	PMID:22575960
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IMP		Human	PMID:24284625
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IDA		Human	PMID:24316715
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IDA		Human	PMID:27281194
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IDA		Human	PMID:27373337
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IDA		Human	PMID:27627798
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IMP		Human	PMID:28297716
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	METTL3	IMP		Human	PMID:9409616
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	Mettl3	IMP		Mouse	MGI:MGI:6094929\|PMID:28792938
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	Mettl3	IMP		Mouse	MGI:MGI:5527005\|PMID:24209618
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	Mettl3	IDA		Mouse	PMID:24394384
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Molecular Function	GO:0003729	mRNA binding	METTL3	IDA		Human	PMID:27281194
Molecular Function	GO:0003729	mRNA binding	METTL3	IDA		Human	PMID:27373337
Molecular Function	GO:0003729	mRNA binding	METTL3	IDA		Human	PMID:30559377
Molecular Function	GO:0005515	protein binding	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:24316715
Molecular Function	GO:0005515	protein binding	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:24394384
Molecular Function	GO:0005515	protein binding	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:27373337
Molecular Function	GO:0005515	protein binding	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:29507755
Molecular Function	GO:0005515	protein binding	Mettl3	IPI	UniProtKB:Q3UIK4	Mouse	MGI:MGI:5559905\|PMID:24394384
Molecular Function	GO:0046982	protein heterodimerization activity	METTL3	IPI	UniProtKB:Q9HCE5	Human	PMID:27281194
Molecular Function	GO:0046982	protein heterodimerization activity	METTL3	IDA		Human	PMID:27373337
Molecular Function	GO:0008173	RNA methyltransferase activity	METTL3	IDA		Human	PMID:25799998
Molecular Function	GO:0008173	RNA methyltransferase activity	METTL3	IDA		Human	PMID:27602518
Molecular Function	GO:0008173	RNA methyltransferase activity	METTL3	IDA		Human	PMID:29348140
Molecular Function	GO:0008173	RNA methyltransferase activity	METTL3	IDA		Human	PMID:29506078
Molecular Function	GO:1904047	S-adenosyl-L-methionine binding	METTL3	IDA		Human	PMID:27281194
Molecular Function	GO:1904047	S-adenosyl-L-methionine binding	METTL3	IDA		Human	PMID:27373337
Cellular Component	GO:0005829	cytosol	METTL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	METTL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	METTL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	METTL3	IDA		Human	PMID:24407421
Cellular Component	GO:0005654	nucleoplasm	METTL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	METTL3	IDA		Human	PMID:24316715
Cellular Component	GO:0005634	nucleus	METTL3	IDA		Human	PMID:26458103
Cellular Component	GO:0005634	nucleus	METTL3	IDA		Human	PMID:29348140
Cellular Component	GO:0005634	nucleus	METTL3	IDA		Human	PMID:29506078
Cellular Component	GO:0005634	nucleus	METTL3	IDA		Human	PMID:9409616
Cellular Component	GO:0005634	nucleus	Mettl3	IDA		Mouse	PMID:28914256
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IPI		Human	PMID:29507755
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:24316715
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:24407421
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:24981863
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:27602518
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:27627798
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:29348140
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:29506078
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	METTL3	IDA		Human	PMID:29507755
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	Mettl3	IDA		Mouse	MGI:MGI:6158697\|PMID:29547716
Biological Process	GO:0006382	adenosine to inosine editing	Mettl3	IMP		Mouse	MGI:MGI:5621227\|PMID:25569111
Biological Process	GO:0034644	cellular response to UV	METTL3	IDA		Human	PMID:28297716
Biological Process	GO:0007623	circadian rhythm	Mettl3	IMP		Mouse	MGI:MGI:5527005\|PMID:24209618
Biological Process	GO:0006974	DNA damage response	METTL3	IDA		Human	PMID:28297716
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	METTL3	IDA		Human	PMID:27602518
Biological Process	GO:0098508	endothelial to hematopoietic transition	mettl3	IMP		Zfish	PMID:28869969\|ZFIN:ZDB-PUB-170905-1
Biological Process	GO:0030317	flagellated sperm motility	mettl3	IMP	ZFIN:ZDB-GENO-180410-3	Zfish	PMID:29196300
Biological Process	GO:0030317	flagellated sperm motility	mettl3	IMP	ZFIN:ZDB-GENO-180410-6	Zfish	PMID:29196300
Biological Process	GO:0021861	forebrain radial glial cell differentiation	Mettl3	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0042063	gliogenesis	Mettl3	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0071425	hematopoietic stem cell proliferation	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Biological Process	GO:0006402	mRNA catabolic process	Mettl3	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0006402	mRNA catabolic process	Mettl3	IMP		Mouse	MGI:MGI:6094929\|PMID:28792938
Biological Process	GO:0006402	mRNA catabolic process	Mettl3	IMP		Mouse	MGI:MGI:6095345\|PMID:28637692
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:6095345\|PMID:28637692
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:5621227\|PMID:25569111
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:5621254\|PMID:25456834
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:6094929\|PMID:28792938
Biological Process	GO:0061157	mRNA destabilization	Mettl3	IMP		Mouse	MGI:MGI:5559905\|PMID:24394384
Biological Process	GO:0080009	mRNA methylation	METTL3	IMP		Human	PMID:22575960
Biological Process	GO:0080009	mRNA methylation	METTL3	IMP		Human	PMID:24284625
Biological Process	GO:0080009	mRNA methylation	METTL3	IDA		Human	PMID:24316715
Biological Process	GO:0080009	mRNA methylation	METTL3	IMP		Human	PMID:25719671
Biological Process	GO:0080009	mRNA methylation	METTL3	IDA		Human	PMID:27281194
Biological Process	GO:0080009	mRNA methylation	METTL3	IDA		Human	PMID:27373337
Biological Process	GO:0080009	mRNA methylation	METTL3	IDA		Human	PMID:27627798
Biological Process	GO:0080009	mRNA methylation	METTL3	IDA		Human	PMID:28297716
Biological Process	GO:0080009	mRNA methylation	Mettl3	IDA		Mouse	MGI:MGI:5927282\|PMID:28965759
Biological Process	GO:0080009	mRNA methylation	Mettl3	IMP		Mouse	MGI:MGI:5621227\|PMID:25569111
Biological Process	GO:0080009	mRNA methylation	Mettl3	IMP		Mouse	MGI:MGI:5527005\|PMID:24209618
Biological Process	GO:0080009	mRNA methylation	Mettl3	IMP		Mouse	MGI:MGI:5621254\|PMID:25456834
Biological Process	GO:0080009	mRNA methylation	Mettl3	IMP		Mouse	MGI:MGI:6094929\|PMID:28792938
Biological Process	GO:0080009	mRNA methylation	Mettl3	IDA		Mouse	PMID:24394384
Biological Process	GO:0080009	mRNA methylation	mettl3	IMP		Zfish	PMID:28869969\|ZFIN:ZDB-PUB-170905-1
Biological Process	GO:0080009	mRNA methylation	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Biological Process	GO:0006397	mRNA processing	Mettl3	IMP		Mouse	MGI:MGI:5527005\|PMID:24209618
Biological Process	GO:0000398	mRNA splicing, via spliceosome	METTL3	IMP		Human	PMID:25719671
Biological Process	GO:0000398	mRNA splicing, via spliceosome	METTL3	IMP		Human	PMID:26321680
Biological Process	GO:0000398	mRNA splicing, via spliceosome	Mettl3	IMP		Mouse	MGI:MGI:5621227\|PMID:25569111
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	mettl3	IMP		Zfish	PMID:28869969\|ZFIN:ZDB-PUB-170905-1
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	METTL3	IMP		Human	PMID:30559377
Biological Process	GO:0060853	Notch signaling pathway involved in arterial endothelial cell fate commitment	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Biological Process	GO:0001556	oocyte maturation	mettl3	IMP	ZFIN:ZDB-GENO-180410-6	Zfish	PMID:29196300
Biological Process	GO:0001556	oocyte maturation	mettl3	IMP	ZFIN:ZDB-GENO-180410-3	Zfish	PMID:29196300
Biological Process	GO:0048477	oogenesis	Mettl3	IMP		Mouse	MGI:MGI:6490006\|PMID:32943573
Biological Process	GO:1903679	positive regulation of cap-independent translational initiation	METTL3	IMP		Human	PMID:26593424
Biological Process	GO:0045727	positive regulation of translation	METTL3	IMP		Human	PMID:30559377
Biological Process	GO:0031053	primary miRNA processing	METTL3	IDA		Human	PMID:25799998
Biological Process	GO:0042981	regulation of apoptotic process	mettl3	IGI	ZFIN:ZDB-MRPHLNO-140428-2,ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:24407421
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	mettl3	IMP		Zfish	PMID:28869969\|ZFIN:ZDB-PUB-170905-1
Biological Process	GO:0051445	regulation of meiotic cell cycle	Mettl3	IMP		Mouse	MGI:MGI:6103202\|PMID:28809392
Biological Process	GO:0090365	regulation of mRNA modification	mettl3	IMP	ZFIN:ZDB-MRPHLNO-140428-3	Zfish	PMID:28869969
Biological Process	GO:0045580	regulation of T cell differentiation	Mettl3	IMP		Mouse	MGI:MGI:6094929\|PMID:28792938
Biological Process	GO:0001510	RNA methylation	METTL3	IMP		Human	PMID:9409616
Biological Process	GO:0001510	RNA methylation	Mettl3	IMP		Mouse	MGI:MGI:6103038\|PMID:28914256
Biological Process	GO:0001510	RNA methylation	Mettl3	IMP		Mouse	MGI:MGI:6095345\|PMID:28637692
Biological Process	GO:0001510	RNA methylation	Mettl3	IMP		Mouse	MGI:MGI:6103202\|PMID:28809392
Biological Process	GO:0007530	sex determination	mettl3	IMP	ZFIN:ZDB-GENO-180410-3	Zfish	PMID:29196300
Biological Process	GO:0007530	sex determination	mettl3	IMP	ZFIN:ZDB-GENO-180410-6	Zfish	PMID:29196300
Biological Process	GO:0007283	spermatogenesis	Mettl3	IMP		Mouse	MGI:MGI:6103202\|PMID:28809392
Biological Process	GO:0007283	spermatogenesis	Mettl3	IMP		Mouse	MGI:MGI:6103038\|PMID:28914256
Biological Process	GO:0007283	spermatogenesis	Mettl3	IMP		Mouse	MGI:MGI:6490006\|PMID:32943573
Biological Process	GO:0019827	stem cell population maintenance	Mettl3	IMP		Mouse	MGI:MGI:5621254\|PMID:25456834
Biological Process	GO:0019827	stem cell population maintenance	Mettl3	IMP		Mouse	MGI:MGI:5559905\|PMID:24394384
Biological Process	GO:0019827	stem cell population maintenance	Mettl3	IMP		Mouse	MGI:MGI:5621227\|PMID:25569111

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.