Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes METTL2A,METTL2B
  • Mouse genes Mettl2
  • Rat genes Mettl2
  • Zfish genes mettl2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mettl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	METTL2B	IPI	UniProtKB:Q5D0E6	Human	PMID:32427860
Molecular Function	GO:0005515	protein binding	METTL2A	IPI	UniProtKB:Q5D0E6	Human	PMID:32427860
Molecular Function	GO:0016427	tRNA (cytosine) methyltransferase activity	METTL2B	IMP		Human	PMID:21518805
Molecular Function	GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	METTL2B	IMP		Human	PMID:28655767
Molecular Function	GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	METTL2A	IMP		Human	PMID:28655767
Molecular Function	GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	METTL2A	IDA		Human	PMID:34268557
Molecular Function	GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	Mettl2	IMP	MGI:MGI:5903740	Mouse	PMID:28655767
Cellular Component	GO:0005737	cytoplasm	METTL2B	IDA		Human	PMID:34268557
Cellular Component	GO:0005737	cytoplasm	METTL2A	IDA		Human	PMID:34268557
Biological Process	GO:0030488	tRNA methylation	METTL2B	IMP		Human	PMID:21518805
Biological Process	GO:0030488	tRNA methylation	METTL2B	IMP		Human	PMID:28655767
Biological Process	GO:0030488	tRNA methylation	METTL2A	IMP		Human	PMID:28655767
Biological Process	GO:0030488	tRNA methylation	METTL2A	IDA		Human	PMID:34268557
Biological Process	GO:0030488	tRNA methylation	Mettl2	IMP	MGI:MGI:5903740	Mouse	PMID:28655767
Biological Process	GO:0006400	tRNA modification	METTL2A	IDA		Human	PMID:34268557

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern