Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LSS
  • Mouse genes Lss
  • Rat genes Lss
  • Zfish genes lss
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lss

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000250	lanosterol synthase activity	LSS	IMP		Human	PMID:26200341
Molecular Function	GO:0000250	lanosterol synthase activity	LSS	IGI	UniProtKB:P38604	Human	PMID:7639730
Molecular Function	GO:0000250	lanosterol synthase activity	Lss	IDA		Rat	PMID:1429550|RGD:2316919
Molecular Function	GO:0000250	lanosterol synthase activity	Lss	IMP		Rat	PMID:16440058|RGD:1626611
Molecular Function	GO:0000250	lanosterol synthase activity	Lss	IDA		Rat	PMID:7568116|RGD:728996
Molecular Function	GO:0000250	lanosterol synthase activity	Lss	IMP		Rat	PMID:7568116|RGD:728996
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:O95070	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q99828	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LSS	IPI	UniProtKB:Q9NRX6	Human	PMID:32296183
Cellular Component	GO:0005789	endoplasmic reticulum membrane	LSS	IDA		Human	PMID:30401459
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Lss	IDA		Rat	PMID:1429550|RGD:2316919
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Lss	IDA		Rat	PMID:16440058|RGD:1626611
Cellular Component	GO:0005811	lipid droplet	LSS	IDA		Human	PMID:14741744
Cellular Component	GO:0005811	lipid droplet	LSS	IDA		Human	PMID:21498505
Cellular Component	GO:0016020	membrane	LSS	HDA		Human	PMID:19946888
Biological Process	GO:0006695	cholesterol biosynthetic process	LSS	IMP		Human	PMID:17186944
Biological Process	GO:0006695	cholesterol biosynthetic process	Lss	IDA		Rat	PMID:1429550|RGD:2316919
Biological Process	GO:0006695	cholesterol biosynthetic process	Lss	IMP		Rat	PMID:16440058|RGD:1626611
Biological Process	GO:0006695	cholesterol biosynthetic process	Lss	IDA		Rat	PMID:7568116|RGD:728996
Biological Process	GO:0006695	cholesterol biosynthetic process	lss	IMP	ZFIN:ZDB-GENO-220408-1	Zfish	PMID:32430393
Biological Process	GO:0032330	regulation of chondrocyte differentiation	lss	IMP	ZFIN:ZDB-GENO-220408-3	Zfish	PMID:32430393
Biological Process	GO:0031647	regulation of protein stability	LSS	IMP		Human	PMID:26200341
Biological Process	GO:0006694	steroid biosynthetic process	LSS	IMP		Human	PMID:26200341
Biological Process	GO:0016125	sterol metabolic process	Lss	IMP		Rat	PMID:16440058|RGD:1626611

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern