Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIN28B
  • Mouse genes Lin28b
  • Rat genes Lin28b
  • Zfish genes lin28b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lin28b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LIN28B	IPI	UniProtKB:Q5TAX3	Human	PMID:19703396
Molecular Function	GO:0003723	RNA binding	LIN28B	IDA		Human	PMID:19703396
Molecular Function	GO:0003723	RNA binding	LIN28B	HDA		Human	PMID:22681889
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	LIN28B	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	LIN28B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	LIN28B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	LIN28B	IDA		Human	GO_REF:0000052
Biological Process	GO:0043009	chordate embryonic development	lin28b	IMP	ZFIN:ZDB-MRPHLNO-140812-1	Zfish	PMID:24516585
Biological Process	GO:0010587	miRNA catabolic process	LIN28B	IMP		Human	PMID:19703396
Biological Process	GO:2000632	negative regulation of pre-miRNA processing	LIN28B	IDA		Human	PMID:18951094
Biological Process	GO:2000635	negative regulation of primary miRNA processing	LIN28B	IDA		Human	PMID:18951094
Biological Process	GO:2000627	positive regulation of miRNA catabolic process	LIN28B	IMP		Human	PMID:18951094
Biological Process	GO:0031054	pre-miRNA processing	LIN28B	IMP		Human	PMID:19703396
Biological Process	GO:0040009	regulation of growth rate	lin28b	IMP	ZFIN:ZDB-GENO-221031-4	Zfish	PMID:31792362
Biological Process	GO:0040009	regulation of growth rate	lin28b	IMP	ZFIN:ZDB-GENO-221031-5	Zfish	PMID:31792362
Biological Process	GO:0031123	RNA 3'-end processing	LIN28B	IMP		Human	PMID:19703396
Biological Process	GO:0050779	RNA destabilization	LIN28B	IDA		Human	PMID:18951094

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern