Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL40
  • Mouse genes Klhl40
  • Rat genes Klhl40
  • Zfish genes klhl40a,klhl40b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl40

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KLHL40	IPI	UniProtKB:Q7L590-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	KLHL40	IPI	UniProtKB:A1L4K1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL40	IPI	UniProtKB:Q5VWN6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL40	IPI	UniProtKB:Q7L590-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL40	IPI	UniProtKB:Q8IYX7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Klhl40	IPI	UniProtKB:Q08639	Mouse	MGI:MGI:5700633|PMID:25940086
Molecular Function	GO:0005515	protein binding	Klhl40	IPI	MGI:MGI:97292	Mouse	PMID:24960163
Molecular Function	GO:0005515	protein binding	Klhl40	IPI	PR:Q9JLV5	Mouse	PMID:24361185
Molecular Function	GO:0005515	protein binding	Klhl40	IPI	PR:E9QA62	Mouse	PMID:24960163
Cellular Component	GO:0031672	A band	Klhl40	IDA		Mouse	PMID:24960163
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	Klhl40	IDA		Mouse	MGI:MGI:5565628|PMID:24361185
Cellular Component	GO:0005737	cytoplasm	Klhl40	IDA		Mouse	MGI:MGI:5700633|PMID:25940086
Cellular Component	GO:0031674	I band	Klhl40	IDA		Mouse	PMID:24960163
Biological Process	GO:0061061	muscle structure development	klhl40a	IGI	ZFIN:ZDB-MRPHLNO-130823-1,ZFIN:ZDB-MRPHLNO-130823-3	Zfish	PMID:23746549
Biological Process	GO:0061061	muscle structure development	klhl40a	IMP	ZFIN:ZDB-MRPHLNO-130823-1	Zfish	PMID:23746549
Biological Process	GO:0061061	muscle structure development	klhl40b	IGI	ZFIN:ZDB-MRPHLNO-130823-1,ZFIN:ZDB-MRPHLNO-130823-3	Zfish	PMID:23746549
Biological Process	GO:0061061	muscle structure development	klhl40b	IMP	ZFIN:ZDB-MRPHLNO-130823-2	Zfish	PMID:23746549
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Klhl40	IDA		Mouse	PMID:24960163
Biological Process	GO:0031397	negative regulation of protein ubiquitination	Klhl40	IDA		Mouse	PMID:24960163
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Klhl40	IDA		Mouse	MGI:MGI:5700633|PMID:25940086
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Klhl40	IDA		Mouse	MGI:MGI:5700633|PMID:25940086
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Klhl40	IDA		Mouse	PMID:24960163
Biological Process	GO:0016567	protein ubiquitination	Klhl40	IDA		Mouse	PMID:24960163
Biological Process	GO:0048741	skeletal muscle fiber development	Klhl40	IMP		Mouse	MGI:MGI:5700633|PMID:25940086
Biological Process	GO:0048741	skeletal muscle fiber development	Klhl40	IMP	MGI:MGI:4843038	Mouse	PMID:24960163
Biological Process	GO:0048741	skeletal muscle fiber development	klhl40a	IMP	ZFIN:ZDB-MRPHLNO-130823-1	Zfish	PMID:23746549
Biological Process	GO:0048741	skeletal muscle fiber development	klhl40b	IMP	ZFIN:ZDB-MRPHLNO-130823-3	Zfish	PMID:23746549
Biological Process	GO:0048741	skeletal muscle fiber development	klhl40b	IMP	ZFIN:ZDB-MRPHLNO-130823-2	Zfish	PMID:23746549
Biological Process	GO:0098528	skeletal muscle fiber differentiation	Klhl40	IMP		Mouse	MGI:MGI:5700633|PMID:25940086
Biological Process	GO:0098528	skeletal muscle fiber differentiation	Klhl40	IMP		Mouse	PMID:24361185
Biological Process	GO:0036268	swimming	klhl40a	IGI	ZFIN:ZDB-MRPHLNO-130823-1,ZFIN:ZDB-MRPHLNO-130823-3	Zfish	PMID:23746549
Biological Process	GO:0036268	swimming	klhl40b	IGI	ZFIN:ZDB-MRPHLNO-130823-1,ZFIN:ZDB-MRPHLNO-130823-3	Zfish	PMID:23746549

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern