Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL18RAP
  • Mouse genes Il18rap
  • Rat genes Il18rap
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il18rap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	IL18RAP	IDA		Human	PMID:25500532
Molecular Function	GO:0042008	interleukin-18 receptor activity	IL18RAP	IDA		Human	PMID:25500532
Molecular Function	GO:0005515	protein binding	IL18RAP	IPI	UniProtKB:O76024	Human	PMID:32814053
Cellular Component	GO:0045092	interleukin-18 receptor complex	IL18RAP	IDA		Human	PMID:25500532
Biological Process	GO:0008283	cell population proliferation	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0071345	cellular response to cytokine stimulus	Il18rap	IEP		Rat	PMID:18547159|RGD:4889457
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Il18rap	IEP		Rat	PMID:12684057|RGD:4889505
Biological Process	GO:0071351	cellular response to interleukin-18	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IL18RAP	IDA		Human	PMID:25500532
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0032635	interleukin-6 production	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0042119	neutrophil activation	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IL18RAP	IDA		Human	PMID:25500532
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532
Biological Process	GO:0032609	type II interferon production	Il18rap	IMP	MGI:MGI:3579137	Mouse	PMID:15843532

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern