Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFIT2
  • Mouse genes Ifit2
  • Rat genes Ifit2
  • Zfish genes ifit10,ifit11,ifit9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifit2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:Q86WV6	Human	PMID:19416887
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:O14879	Human	PMID:21190939
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:P09914	Human	PMID:21190939
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:O14879	Human	PMID:21642987
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:P09914	Human	PMID:21642987
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:O14879	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:P09914	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFIT2	IPI	UniProtKB:O14879	Human	PMID:31515488
Molecular Function	GO:0003723	RNA binding	IFIT2	HDA		Human	PMID:22658674
Cellular Component	GO:0005737	cytoplasm	IFIT2	IDA		Human	PMID:21190939
Cellular Component	GO:0005783	endoplasmic reticulum	IFIT2	IDA		Human	PMID:21190939
Biological Process	GO:0140374	antiviral innate immune response	Ifit2	IDA		Mouse	PMID:31390091
Biological Process	GO:0035457	cellular response to interferon-alpha	Ifit2	IDA		Mouse	PMID:7896268
Biological Process	GO:0051607	defense response to virus	ifit10	IDA		Zfish	PMID:24950240
Biological Process	GO:0032091	negative regulation of protein binding	IFIT2	IDA		Human	PMID:19416887
Biological Process	GO:0043065	positive regulation of apoptotic process	IFIT2	IDA		Human	PMID:21190939
Biological Process	GO:0009615	response to virus	IFIT2	IDA		Human	PMID:19416887
Biological Process	GO:0009615	response to virus	IFIT2	IMP		Human	PMID:21642987
Biological Process	GO:0009615	response to virus	Ifit2	IMP		Mouse	MGI:MGI:5437423|PMID:21085181

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern