Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-H
  • Mouse genes H2-Q8
  • Rat genes RT1-A1,RT1-A2,RT1-CE1,RT1-CE10,RT1-CE15,RT1-CE2,RT1-CE5,RT1-CE7
  • Zfish genes mhc1lea,mhc1lja,mhc1zaa,mhc1zba,mhc1zca,mhc1zea,mhc1zfa,mhc1zja,mhc1zka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-Q8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-H	IMP		Human	PMID:9162021
Molecular Function	GO:0030881	beta-2-microglobulin binding	RT1-A1	IPI	RGD:2189	Rat	PMID:11773898|RGD:2313503
Molecular Function	GO:0042277	peptide binding	RT1-A1	IDA		Rat	PMID:10856297|RGD:2313508
Molecular Function	GO:0005515	protein binding	HLA-H	IPI	UniProtKB:P11142	Human	PMID:29764935
Molecular Function	GO:0005515	protein binding	RT1-A2	IPI	RGD:3818	Rat	PMID:12817008|RGD:2313509
Molecular Function	GO:0005515	protein binding	RT1-A1	IPI	RGD:3818	Rat	PMID:12817008|RGD:2313509
Molecular Function	GO:0044877	protein-containing complex binding	RT1-A1	IPI	RGD:735892	Rat	PMID:8597563|RGD:2313510
Cellular Component	GO:0009986	cell surface	HLA-H	IMP		Human	PMID:9162021
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	RT1-A1	IMP		Rat	PMID:10837412|RGD:2313500
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	RT1-A1	IDA		Rat	PMID:11773898|RGD:2313503
Biological Process	GO:0002657	positive regulation of tolerance induction to nonself antigen	RT1-A1	IMP		Rat	PMID:16000395|RGD:2313504
Biological Process	GO:0002517	T cell tolerance induction	RT1-A1	IMP		Rat	PMID:16000395|RGD:2313504

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern