Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ESPN
  • Mouse genes Espn
  • Rat genes Espn
  • Zfish genes espn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Espn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Espn	IDA		Rat	PMID:8799813|RGD:632658
Molecular Function	GO:0005515	protein binding	Espn	IPI	UniProtKB:Q1EG27|UniProtKB:Q8K3H5	Mouse	MGI:MGI:5805759|PMID:26926603
Molecular Function	GO:0005515	protein binding	Espn	IPI	PR:Q1EG27	Mouse	PMID:22264607
Molecular Function	GO:0017124	SH3 domain binding	Espn	IPI	UniProtKB:Q9UQB8	Rat	PMID:12598619|RGD:632657
Cellular Component	GO:0015629	actin cytoskeleton	Espn	IDA		Mouse	PMID:10588661
Cellular Component	GO:0015629	actin cytoskeleton	Espn	IDA		Rat	PMID:16413524|RGD:8554030
Cellular Component	GO:0005903	brush border	Espn	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0005903	brush border	Espn	IDA		Rat	PMID:9763424|RGD:632659
Cellular Component	GO:0005737	cytoplasm	Espn	IDA		Rat	PMID:16413524|RGD:8554030
Cellular Component	GO:0031941	filamentous actin	Espn	IDA		Rat	PMID:8799813|RGD:632658
Cellular Component	GO:0005902	microvillus	ESPN	IDA		Human	PMID:29572253
Cellular Component	GO:0005902	microvillus	Espn	IDA		Rat	PMID:16413524|RGD:8554030
Cellular Component	GO:0032420	stereocilium	ESPN	IDA		Human	PMID:29572253
Cellular Component	GO:0032420	stereocilium	Espn	IDA		Mouse	PMID:20510926
Cellular Component	GO:0032421	stereocilium bundle	Espn	IDA		Mouse	PMID:20016102
Cellular Component	GO:0032426	stereocilium tip	Espn	IDA		Mouse	MGI:MGI:5766107|PMID:26754646
Cellular Component	GO:0032426	stereocilium tip	Espn	EXP		Mouse	PMID:26754646
Cellular Component	GO:0032426	stereocilium tip	Espn	IDA		Mouse	PMID:22264607
Biological Process	GO:0051017	actin filament bundle assembly	Espn	IDA		Mouse	PMID:10588661
Biological Process	GO:0048858	cell projection morphogenesis	espn	IMP	ZFIN:ZDB-GENO-200320-3	Zfish	PMID:31002663
Biological Process	GO:0007626	locomotory behavior	Espn	IMP	MGI:MGI:1856573	Mouse	PMID:16962269
Biological Process	GO:0030034	microvillar actin bundle assembly	ESPN	IMP		Human	PMID:29572253
Biological Process	GO:0051494	negative regulation of cytoskeleton organization	Espn	IDA		Mouse	MGI:MGI:3688341|PMID:15190118
Biological Process	GO:0030046	parallel actin filament bundle assembly	Espn	IDA		Mouse	PMID:10588661
Biological Process	GO:0051491	positive regulation of filopodium assembly	Espn	IGI	MGI:MGI:2183924	Mouse	PMID:22264607
Biological Process	GO:0051491	positive regulation of filopodium assembly	Espn	IPI	PR:Q1EG27	Mouse	PMID:22264607

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern