Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP21A1P,CYP21A2
  • Mouse genes Cyp21a1
  • Rat genes Cyp21a1
  • Zfish genes cyp21a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp21a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0103069	17-hydroxyprogesterone 21-hydroxylase activity	CYP21A2	IDA		Human	PMID:25855791
Molecular Function	GO:0020037	heme binding	CYP21A2	IDA		Human	PMID:25855791
Molecular Function	GO:0106309	progesterone 21-hydroxylase activity	CYP21A2	IDA		Human	PMID:25855791
Molecular Function	GO:0004509	steroid 21-monooxygenase activity	Cyp21a1	IDA		Rat	PMID:9408081|RGD:1298842
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP21A2	IMP		Human	PMID:16984992
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	Cyp21a1	IMP		Rat	PMID:9408081|RGD:1298842
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Cyp21a1	IEP		Rat	PMID:7588239|RGD:4891141
Biological Process	GO:0006704	glucocorticoid biosynthetic process	cyp21a2	IMP	ZFIN:ZDB-GENO-180511-1	Zfish	PMID:28938470
Biological Process	GO:0006705	mineralocorticoid biosynthetic process	Cyp21a1	IDA		Rat	PMID:19665544|RGD:4891164
Biological Process	GO:0042448	progesterone metabolic process	Cyp21a1	IDA		Rat	PMID:19665544|RGD:4891164
Biological Process	GO:0046677	response to antibiotic	Cyp21a1	IEP		Rat	PMID:19733641|RGD:4460910
Biological Process	GO:0006694	steroid biosynthetic process	CYP21A2	IDA		Human	PMID:25855791
Biological Process	GO:0008202	steroid metabolic process	CYP21A2	IMP		Human	PMID:16984992

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern