Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNA1H
  • Mouse genes Cacna1h
  • Rat genes Cacna1h
  • Zfish genes cacna1ha,cacna1hb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna1h

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008332	low voltage-gated calcium channel activity	CACNA1H	IDA		Human	PMID:21084288
Molecular Function	GO:0008332	low voltage-gated calcium channel activity	Cacna1h	IDA		Rat	PMID:11073957|RGD:68748
Molecular Function	GO:0008332	low voltage-gated calcium channel activity	Cacna1h	IDA		Rat	PMID:16935432|RGD:7207257
Molecular Function	GO:0005515	protein binding	CACNA1H	IPI	UniProtKB:P97306	Human	PMID:27149520
Molecular Function	GO:0005515	protein binding	Cacna1h	IPI	PR:P51637	Mouse	PMID:21084288
Molecular Function	GO:0097110	scaffold protein binding	CACNA1H	IPI	UniProtKB:P56539	Human	PMID:21084288
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	CACNA1H	IDA		Human	PMID:27149520
Cellular Component	GO:0005901	caveola	Cacna1h	IDA		Mouse	PMID:21084288
Cellular Component	GO:0005737	cytoplasm	Cacna1h	IDA		Rat	PMID:16736476|RGD:1582593
Cellular Component	GO:0030425	dendrite	Cacna1h	IDA		Rat	PMID:16736476|RGD:1582593
Cellular Component	GO:0098978	glutamatergic synapse	Cacna1h	IDA		Mouse	PMID:21358644
Cellular Component	GO:0016020	membrane	CACNA1H	IDA		Human	PMID:21084288
Cellular Component	GO:0005634	nucleus	Cacna1h	IDA		Rat	PMID:16736476|RGD:1582593
Cellular Component	GO:0043204	perikaryon	Cacna1h	IDA		Rat	PMID:16736476|RGD:1582593
Cellular Component	GO:0005886	plasma membrane	CACNA1H	IDA		Human	PMID:27149520
Cellular Component	GO:0045211	postsynaptic membrane	Cacna1h	IDA		Mouse	PMID:21358644
Cellular Component	GO:0048787	presynaptic active zone membrane	Cacna1h	IDA		Mouse	PMID:21358644
Cellular Component	GO:0042383	sarcolemma	Cacna1h	IDA		Mouse	PMID:21084288
Biological Process	GO:0032342	aldosterone biosynthetic process	CACNA1H	IMP		Human	PMID:19342457
Biological Process	GO:0032342	aldosterone biosynthetic process	Cacna1h	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:0070509	calcium ion import	CACNA1H	IDA		Human	PMID:21084288
Biological Process	GO:0070509	calcium ion import	Cacna1h	IDA		Rat	PMID:16935432|RGD:7207257
Biological Process	GO:0070509	calcium ion import	Cacna1h	IMP		Rat	PMID:19443576|RGD:7205486
Biological Process	GO:0006816	calcium ion transport	Cacna1h	IDA		Rat	PMID:11073957|RGD:68748
Biological Process	GO:0032870	cellular response to hormone stimulus	CACNA1H	IEP		Human	PMID:19342457
Biological Process	GO:0035865	cellular response to potassium ion	CACNA1H	IEP		Human	PMID:19342457
Biological Process	GO:0034651	cortisol biosynthetic process	CACNA1H	IMP		Human	PMID:19342457
Biological Process	GO:0034651	cortisol biosynthetic process	Cacna1h	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:0098662	inorganic cation transmembrane transport	CACNA1H	IDA		Human	PMID:27149520
Biological Process	GO:2000344	positive regulation of acrosome reaction	CACNA1H	IMP		Human	PMID:20394732
Biological Process	GO:0106134	positive regulation of cardiac muscle cell contraction	Cacna1h	IMP		Rat	PMID:19443576|RGD:7205486
Biological Process	GO:0042391	regulation of membrane potential	CACNA1H	IDA		Human	PMID:21084288
Biological Process	GO:0019233	sensory perception of pain	Cacna1h	IMP		Rat	PMID:19167819|RGD:7205484

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern