Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCG5
  • Mouse genes Abcg5
  • Rat genes Abcg5
  • Zfish genes abcg5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcg5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ABCG5	IDA		Human	PMID:16893193
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCG5	IDA		Human	PMID:16893193
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCG5	IDA		Human	PMID:27144356
Molecular Function	GO:0120020	cholesterol transfer activity	ABCG5	IGI	UniProtKB:Q99PE8	Human	PMID:14504269
Molecular Function	GO:0120020	cholesterol transfer activity	Abcg5	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Molecular Function	GO:0005515	protein binding	ABCG5	IPI	UniProtKB:Q9H221	Human	PMID:16870176
Molecular Function	GO:0005515	protein binding	ABCG5	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	Abcg5	IPI	UniProtKB:Q9DBM0	Mouse	MGI:MGI:6095614|PMID:12208867
Molecular Function	GO:0046982	protein heterodimerization activity	ABCG5	IPI	UniProtKB:Q9H221	Human	PMID:16870176
Molecular Function	GO:0046982	protein heterodimerization activity	Abcg5	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0045177	apical part of cell	Abcg5	IDA		Mouse	PMID:15040800
Cellular Component	GO:0016324	apical plasma membrane	ABCG5	IMP		Human	PMID:14504269
Cellular Component	GO:0016324	apical plasma membrane	Abcg5	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0016324	apical plasma membrane	Abcg5	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Cellular Component	GO:0016324	apical plasma membrane	Abcg5	IDA		Mouse	MGI:MGI:3695229|PMID:16867993
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	ABCG5	IDA		Human	PMID:16893193
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	ABCG5	IDA		Human	PMID:27144356
Cellular Component	GO:0016020	membrane	Abcg5	IDA		Mouse	PMID:15040800
Cellular Component	GO:0005886	plasma membrane	Abcg5	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0043235	receptor complex	ABCG5	IDA		Human	PMID:14504269
Cellular Component	GO:0043235	receptor complex	Abcg5	IDA		Mouse	MGI:MGI:2681374|PMID:14504269
Biological Process	GO:0038183	bile acid signaling pathway	Abcg5	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0033344	cholesterol efflux	ABCG5	IGI	UniProtKB:Q99PE8	Human	PMID:14504269
Biological Process	GO:0033344	cholesterol efflux	ABCG5	IMP		Human	PMID:27144356
Biological Process	GO:0033344	cholesterol efflux	Abcg5	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Biological Process	GO:0042632	cholesterol homeostasis	ABCG5	IMP		Human	PMID:11099417
Biological Process	GO:0042632	cholesterol homeostasis	ABCG5	IMP		Human	PMID:27144356
Biological Process	GO:0042632	cholesterol homeostasis	Abcg5	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0045796	negative regulation of intestinal cholesterol absorption	ABCG5	IMP		Human	PMID:11099417
Biological Process	GO:0010949	negative regulation of intestinal phytosterol absorption	ABCG5	IMP		Human	PMID:11099417
Biological Process	GO:0010212	response to ionizing radiation	Abcg5	IEP		Rat	PMID:17132608|RGD:1598660
Biological Process	GO:0014850	response to muscle activity	Abcg5	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0007584	response to nutrient	Abcg5	IEP		Rat	PMID:15710224|RGD:1598545
Biological Process	GO:0031667	response to nutrient levels	Abcg5	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0031667	response to nutrient levels	Abcg5	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0031667	response to nutrient levels	Abcg5	IEP		Rat	PMID:25612518|RGD:15045599
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcg5	IEP		Rat	PMID:17109865|RGD:1598661
Biological Process	GO:0015918	sterol transport	Abcg5	IDA		Mouse	MGI:MGI:3695229|PMID:16867993
Biological Process	GO:0070328	triglyceride homeostasis	Abcg5	IEP		Rat	PMID:23117815|RGD:15045604

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern