Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCC8
  • Mouse genes Abcc8
  • Rat genes Abcc8
  • Zfish genes abcc8,abcc8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcc8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	Abcc8	IDA		Mouse	PMID:7502040
Molecular Function	GO:0005524	ATP binding	Abcc8	IDA		Mouse	PMID:7502040
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ABCC8	IDA		Human	PMID:26181369
Molecular Function	GO:0070320	inward rectifier potassium channel inhibitor activity	Abcc8	IDA		Mouse	PMID:7502040
Molecular Function	GO:0099104	potassium channel activator activity	Abcc8	IDA		Mouse	PMID:7502040
Molecular Function	GO:0005267	potassium channel activity	ABCC8	IMP		Human	PMID:24814349
Molecular Function	GO:0005267	potassium channel activity	ABCC8	IMP		Human	PMID:25720052
Molecular Function	GO:0005267	potassium channel activity	ABCC8	IMP		Human	PMID:26181369
Molecular Function	GO:0044325	transmembrane transporter binding	ABCC8	IPI	UniProtKB:Q14654	Human	PMID:20610380
Cellular Component	GO:0008282	inward rectifying potassium channel	ABCC8	IPI		Human	PMID:29286281
Cellular Component	GO:0008282	inward rectifying potassium channel	ABCC8	IDA		Human	PMID:20610380
Cellular Component	GO:0008282	inward rectifying potassium channel	Abcc8	IDA		Rat	PMID:24114458|RGD:10003028
Cellular Component	GO:0005739	mitochondrion	Abcc8	IDA		Rat	PMID:22466787|RGD:12791999
Cellular Component	GO:0005886	plasma membrane	Abcc8	IGI	MGI:MGI:107501	Mouse	PMID:7502040
Cellular Component	GO:0005886	plasma membrane	Abcc8	IDA		Mouse	PMID:7502040
Cellular Component	GO:0005886	plasma membrane	Abcc8	IDA		Mouse	PMID:16085792
Cellular Component	GO:0042383	sarcolemma	Abcc8	IDA		Rat	PMID:15647111|RGD:1598637
Cellular Component	GO:0030672	synaptic vesicle membrane	Abcc8	IDA		Rat	PMID:14645230|RGD:1549870
Biological Process	GO:0071310	cellular response to organic substance	Abcc8	IDA		Rat	PMID:15613469|RGD:1598638
Biological Process	GO:0007565	female pregnancy	Abcc8	IEP		Rat	PMID:21527399|RGD:12792000
Biological Process	GO:0001678	intracellular glucose homeostasis	Abcc8	IMP		Rat	PMID:23828271|RGD:12792253
Biological Process	GO:0007613	memory	Abcc8	IMP		Rat	PMID:24114458|RGD:10003028
Biological Process	GO:0016525	negative regulation of angiogenesis	Abcc8	IMP		Rat	PMID:23149556|RGD:12790979
Biological Process	GO:1905604	negative regulation of blood-brain barrier permeability	Abcc8	IMP		Rat	PMID:18854840|RGD:2325137
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Abcc8	IMP		Rat	PMID:23149556|RGD:12790979
Biological Process	GO:0046676	negative regulation of insulin secretion	Abcc8	IDA		Mouse	PMID:25771886
Biological Process	GO:0046676	negative regulation of insulin secretion	Abcc8	IMP	MGI:MGI:2388392	Mouse	PMID:16924481
Biological Process	GO:0046676	negative regulation of insulin secretion	Abcc8	IDA		Rat	PMID:15163199|RGD:1598646
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	Abcc8	IMP		Rat	PMID:23828271|RGD:12792253
Biological Process	GO:0061855	negative regulation of neuroblast migration	Abcc8	IMP		Rat	PMID:23149556|RGD:12790979
Biological Process	GO:0050768	negative regulation of neurogenesis	Abcc8	IMP		Rat	PMID:23149556|RGD:12790979
Biological Process	GO:0061045	negative regulation of wound healing	Abcc8	IMP		Rat	PMID:20410530|RGD:12790978
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Abcc8	IMP	MGI:MGI:2388392	Mouse	PMID:16924481
Biological Process	GO:0043268	positive regulation of potassium ion transport	Abcc8	IDA		Rat	PMID:15962003|RGD:1598636
Biological Process	GO:1905075	positive regulation of tight junction disassembly	Abcc8	IMP		Rat	PMID:23633925|RGD:12791991
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Abcc8	IMP		Rat	PMID:18854840|RGD:2325137
Biological Process	GO:1900721	positive regulation of uterine smooth muscle relaxation	Abcc8	IMP		Rat	PMID:25891870|RGD:12790980
Biological Process	GO:1903818	positive regulation of voltage-gated potassium channel activity	Abcc8	IMP		Rat	PMID:12183335|RGD:728122
Biological Process	GO:0032868	response to insulin	Abcc8	IEP		Rat	PMID:18084728|RGD:2301910
Biological Process	GO:0032496	response to lipopolysaccharide	Abcc8	IEP		Rat	PMID:17285300|RGD:2301914
Biological Process	GO:0009268	response to pH	Abcc8	IDA		Rat	PMID:15613469|RGD:1598638
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcc8	IEP		Rat	PMID:17174476|RGD:2301915
Biological Process	GO:0010043	response to zinc ion	Abcc8	IDA		Rat	PMID:15613469|RGD:1598638
Biological Process	GO:0008542	visual learning	Abcc8	IMP		Rat	PMID:24114458|RGD:10003028

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern